Results 171 to 180 of about 52,035 (209)

Mechanisms of Tumor Cell Invasion: Insights From the Perspective of Epithelial‐to‐Mesenchymal Transition

Cell Biochemistry and Function, Volume 44, Issue 11, November 2026.
ABSTRACT Tumor invasion implies aberrantly increased cell motility, and is the first step of the cascade of events culminating in the development of distant metastases. The emergence of migratory capacity in epithelial carcinomas, consisting essentially of stationary cells, is linked to the activation of the epithelial‐to‐mesenchymal transition (EMT ...
Marcello Guarino
wiley   +1 more source

Genetic Structure of Harbour Seals Phoca vitulina vitulina Along the Coast of Norwegian Mainland: Implications for Management

Ecology and Evolution, Volume 16, Issue 11, November 2026.
A nationwide genetic analysis of harbour seals (Phoca vitulina) in Norway revealed significant population structure consistent with isolation by distance. The results suggest that some large northern counties may contain multiple distinct management units, while several south‐eastern counties show no detectable differentiation.
María Quintela, Anne Kirstine Frie, Roger Lille‐Langøy, Ralph Tiedemann, Kjell Tormod Nilssen   +4 more
wiley   +1 more source

Dietary Polyphenols as Regulators of Protein Deposition and Muscle Health: Mechanisms, Interactions, and Functional Applications

Food Science &Nutrition, Volume 14, Issue 11, November 2026.
Dietary polyphenols contribute to the regulation of protein deposition and muscle health through multiple interconnected mechanisms. They promote protein synthesis and myogenic differentiation mainly by modulating the PI3K/AKT/mTOR signaling pathway and myogenic regulatory factors, while suppressing excessive protein degradation through regulation of ...
Chen Liu, Mengyi Ren, Xin Lai, Ke Gu, Liqiang Tan, Aimin Wu, Daiwen Chen   +6 more
wiley   +1 more source

Colonic Barrier Dysfunction and Inflammation Induced by Nano‐/Micro‐Plastics Fibers in Mice via the FAK/NF‐κB/iNOS and TLR4/NF‐κB/iNOS Pathways

Journal of Applied Toxicology, Volume 46, Issue 11, Page 4144-4159, November 2026.
ABSTRACT As emerging environmental contaminants, nano‐ and micro‐plastics (NMPs) have drawn increasing research attention due to potential hazards to organisms. Particle shape is a key factor influencing the toxic effects of NMPs, and NMPs of different shapes cause varying degrees of tissue damage. We investigated the specific mechanisms of polystyrene
Yuting Li, Shibo Bao, Puyang Huang, Jiahui Wang, Hongfeng Li, Yahong Liu, Kai Wang, Jianjun Du, Lingjun Yan, Guowei Pan, Wei Sun   +10 more
wiley   +1 more source

Hydrocalumite‐Like Material Induces Early Osteogenic Priming and ECM Remodeling Without Effective Mineralization in Preosteoblasts

Journal of Biomedical Materials Research Part A, Volume 114, Issue 11, November 2026.
ABSTRACT Hydrocalumite‐like phases, belonging to the layered double hydroxide family, are potential biomaterials for bone repair; however, their cellular effects remain incompletely understood. Here, we evaluated a hydrocalumite‐like material of composition [Ca2Al(OH)₆]Cl·nH2O (abbreviated Ca2Al–Cl) in preosteoblastic MC3T3‐E1 cells, assessing ...
C. J. da Costa Fernandes, G. S. de Almeida, M. Pires Figueiredo, V. R. L. Constantino, W. F. Zambuzzi   +4 more
wiley   +1 more source

Extracellular Vesicles for Space Biomedical Research

Journal of Extracellular Vesicles, Volume 15, Issue 11, November 2026.
Microgravity reshapes EV biogenesis and cargo selection, which brings new opportunities for longitudinal liquid‐biopsy readouts of stress and aging‐like trajectories, as well as the regenerative products in spaceflight research. ABSTRACT Extracellular vesicles (EVs) are regulated, information‐rich nanovesicles that reflect aspects of parent‐cell state,
Samantha Ali, Brian I. Molina Diaz, Pei Zhuang, Zachary Greenberg, Ye Zhang, Jeffrey Richards, Danny Carlos, Stefanie Countryman, Christiaan Leeuwenburgh, Luke P. Lee, Mei He   +10 more
wiley   +1 more source

MYH11–LMOD1 Axis Promotes Ferroptosis and Inhibits Migration and Invasion in Non–Small‐Cell Lung Cancer

The Journal of Gene Medicine, Volume 28, Issue 11, November 2026.
LMOD1, transcriptionally activated by MYH11, functions as a tumor suppressor in NSCLC by enhancing ferroptosis and suppressing cancer cell migration and invasion. ABSTRACT Background Ferroptosis has emerged as a critical mechanism influencing the development of non–small‐cell lung cancer (NSCLC).
Biyun Lin, Yuhao Xu, Shuhong Liu, Mingjun Wang, Lanqi Shi, Chunyuan Chen   +5 more
wiley   +1 more source

The Efferocytosis‐Driven Macrophage Polarization: A Concerto in the Tumor Immunosuppressive Microenvironment

MedComm, Volume 7, Issue 11, November 2026.
Efferocytosis is a key process for macrophages to clear apoptotic cells, which undergoes the “ Find Me” chemotaxis signal stage, the “eat me” phagocytosis recognition stage and the “digest me” digestion stage in turn. During the aforementioned three stages, various signaling molecules released by apoptotic cells can promote the phenotypic polarization ...
Qiuping Chen, Chunzhi Wu, Changquan Huang, Hang Zhou   +3 more
wiley   +1 more source

Highlighting TaRget Enablement to Accelerate Therapy Development for Alzheimer's Disease (TREAT‐AD) centers

Alzheimer's &Dementia, Volume 22, Issue 11, November 2026.
Allan I. Levey, Alan D. Palkowitz
wiley   +1 more source

The PIEZO1/CISD1/IP3R Mechanotransduction Axis Drives Macrophage Mitochondrial Dysfunction and Inflammatory Activation in Pulmonary Fibrosis

MedComm, Volume 7, Issue 11, November 2026.
In the pulmonary fibrotic microenvironment, mechanical signals activate PIEZO1 to mediate Ca2+ entry into macrophages. Increased CISD1/IP3R activity promotes Ca2+ transfer from the endoplasmic reticulum to mitochondria, leading to mitochondrial Ca2+ overload and opening of the mitochondrial permeability transition pore (MPTP). Consequently, macrophages
Yungeng Wei, Chao Xie, Xiangsheng Yang, Xiao Xiao Tang   +3 more
wiley   +1 more source