Results 61 to 70 of about 168,943 (310)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

The Nuremberg Code-A critique

open access: yesPerspectives in Clinical Research, 2011
The Nuremberg Code drafted at the end of the Doctor′s trial in Nuremberg 1947 has been hailed as a landmark document in medical and research ethics. Close examination of this code reveals that it was based on the Guidelines for Human Experimentation of ...
Ravindra B Ghooi
doaj   +1 more source

Are philosophers responsible for global warming? [PDF]

open access: yes, 2008
Global warming has come about as a result of rapid population increase plus our whole modern way of life, all made possible by modern science. In order to tackle global warming successfully, we need a new kind of inquiry that gives intellectual priority ...
Maxwell, N.
core   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

open access: yesFEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi   +7 more
wiley   +1 more source

Paul's Common Paraenesis (1 Thess. 4-5; Phil. 2-4; and Rom. 12-13): The Correspondence between Romans 1:18-32 and 12:1-2, and the Unity of Romans 12-13

open access: yesTyndale Bulletin, 2011
First Thessalonians 5:12-24; Romans 12:9-21; and Philippians 4:2-9 show close parallels, while their wider contexts (1 Thess. 4–5; Rom. 12–13; and Phil. 3:17–4:9) also display a substantial parallelism.
Seyoon Kim
doaj   +1 more source

Religion and modernity in Spain: religious experience in the novels of Ramón Pérez de Ayala [PDF]

open access: yes, 2011
While Ramón Pérez de Ayala is widely regarded as a leading liberal with strong anti-Catholic and indeed anti-religious views, a close examination of his novels reveals a more ambivalent attitude to religious experience.
Macklin, J.
core   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

open access: yesFEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake   +4 more
wiley   +1 more source

Violence and Freedom: A Phenomenological Inquiry into the Practices of Freedom

open access: yesCхід
 It’s difficult to give an account of human history without alluding to the reigns of terror and the fascination with violence perpetrated in the name of freedom and justice. Freedom and violence are two contrasting concepts that have shaped the history
Amon Bekele
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

The Presentation of Postmodern Sexuality in Short Fiction [PDF]

open access: yes, 2018
Shifting norms in twentieth century western society, coupled with emerging postmodern thought in the 1960s, radically changed the ways in which people viewed sexuality, gender roles, and the institutions of marriage and the family.
Kapus, Allie J
core   +1 more source

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