Results 131 to 140 of about 17,506 (246)

Oncolytic Therapy: Delivery System and New Therapeutic Strategies for Cancer

MedComm, Volume 7, Issue 4, April 2026.
This review summarizes recent advances in nanoparticle‐ and cell‐mediated OVs delivery strategies that improve biodistribution and tumor targeting while limiting immune clearance. It also examines combination approaches that enhance therapeutic efficacy through tumor microenvironment modulation or immune activation, thereby overcoming immunosuppression
Sikan Jin, Yi Zhang, Ziling Zhou, Yaqi Zhang, Ting Yu, Rui Xu, Lin Xu, Jidong Zhang, Longze Zhang, Shan Yang, Xianyao Wang   +10 more
wiley   +1 more source

Management of Gastrointestinal Function in Patients After Laparoscopic Surgery for Benign Gynaecological Diseases: A Best Practice Implementation Project

Nursing Open, Volume 13, Issue 4, April 2026.
ABSTRACT Introduction Laparoscopy is widely used in benign gynaecological surgeries. However, postoperative gastrointestinal dysfunction, abdominal distension, abdominal pain, nausea, vomiting and delayed defecation are often negatively affected after surgery. At present, the management of gastrointestinal function in these patients is not standardised;
Mengdan Zhou, Aiping Fu, Shuixian Zhang, Li Ning   +3 more
wiley   +1 more source

Feasibility and Outcomes of a Robotic Retroperitoneal Approach to Para‐Aortic Lymphadenectomy in Intermediate‐ and High‐Risk Endometrial Cancer: A Prospective Study

The International Journal of Medical Robotics and Computer Assisted Surgery, Volume 22, Issue 2, April 2026.
ABSTRACT Background This prospective feasibility study evaluated the safety and efficacy of robotic retroperitoneal para‐aortic lymphadenectomy in patients with intermediate‐to high‐risk endometrial cancer. Methods Patients with endometrial cancer who underwent robotic surgical staging at Mie University Hospital between October 2021 and May 2025 were ...
Michiko Kubo‐Kaneda, Kenta Yoshida, Saki Kotaka, Asumi Okumura, Tsuyoshi Mastumoto, Kota Okamoto, Eiji Kondo   +6 more
wiley   +1 more source

Pelvic Exenteration: Oncological and Surgical Outcomes From a Single Tertiary Statewide Service

ANZ Journal of Surgery, Volume 96, Issue 4, Page 964-971, April 2026.
ABSTRACT Background Advancements in the multidisciplinary management of locally advanced and recurrent rectal cancer, as well as advanced pelvic malignancies, have significantly improved oncological outcomes. Pelvic exenteration is a complex procedure involving en bloc resection of the involved organs with the aim of achieving a microscopic negative ...
Elena T. Blyth, Michael R. Lonne, Kandice B. Keogh, Jane E. Theodore, Craig A. Harris   +4 more
wiley   +1 more source

Refining Tumor Mutational Burden as a Predictive Biomarker for Pembrolizumab: A Real‐World Analysis in Japanese Patients

Cancer Science, Volume 117, Issue 4, Page 1158-1166, April 2026.
In this study, we investigated the predictive value of tumor mutational burden (TMB) for assessing the efficacy of pembrolizumab in a Japanese cohort. We analyzed real‐world data from 63,952 patients registered in the C‐CAT database who underwent comprehensive genomic profiling, and evaluated the therapeutic efficacy of pembrolizumab in 1899 of these ...
Tomoyo Yasuda, Mio Yumura, Azusa Hamasaki, Tongyi Fei, Takashi Kubo, Hitoshi Ichikawa, Takashi Kohno, Kuniko Sunami   +7 more
wiley   +1 more source

Unraveling the Genetic Mysteries of Müllerian Anomalies: Research Approaches and Clinical Significance

Clinical Genetics, Volume 109, Issue 4, Page 615-629, April 2026.
This review primarily summarizes the genetic defects in Müllerian anomalies, the tools used to validate these genetic defects, and the future clinical significance of identifying the precise genetic etiology of Müllerian anomalies. ABSTRACT Müllerian anomalies are a collection of heterogeneous anatomical disorders of the female genital tract that ...
Jingfang Li, Xin Hou, Xiangyu Wang, Juan Li, Li Li, Xiangyi Ma   +5 more
wiley   +1 more source

Ethical and Regulatory Considerations in the Clinical Translation of Pluripotent Stem Cell‐Derived NK Cell Therapies

Cell Proliferation, Volume 59, Issue 4, April 2026.
Advancements in the generation of human pluripotent stem cell‐derived natural killer (PSC‐NK) cells have attracted considerable attention within the biomedical research community, offering a promising off‐the‐shelf technique for universal immune therapy.
Qianwen Chen, Jianwei Lv, Xinwei Xie, Hanlin Zhu, Zhenyu Xiao, Yaojin Peng   +5 more
wiley   +1 more source

Paratubal Leiomyoma Mimicking Ovarian Malignancy: A Case Report and Literature Review. [PDF]

Diagnostics (Basel)
Hsieh WL, Ding DC.
europepmc   +1 more source

Advanced primary fallopian tube cancer was found during chemotherapy for multiple myeloma: a case report and literature. [PDF]

BMC Womens Health
Xi X, Xu R, Li Y, Zhang D, Sun Y, Liu Y, Du X, Hao Z, Wang L, Du J.   +9 more
europepmc   +1 more source

Secondary <i>POLE</i> Mutation Drives Metastasis in Hereditary Breast and Ovarian Cancer: Revealing Fallopian Tube Ultramutation. [PDF]

JCO Precis Oncol
Jisaka M, Nakamura K, Chiyoda T, Iwata T, Masuda K, Kawano R, Funata S, Takamatsu R, Nishihara H, Yamagami W.   +9 more
europepmc   +1 more source