Results 31 to 40 of about 3,131,355 (307)

A phase 1 evaluation of the safety and tolerability of niraparib in combination with everolimus in advanced ovarian and breast cancers

Cancer Medicine, 2023
Objectives Phase 1 trial to determine the safety and tolerability of everolimus and niraparib in patients with advanced ovarian and breast malignancies.
David Starks, Luis Rojas‐Espaillat, Tobias Meissner, Rachel Elsey, Bing Xu, Maria Koenen, Shelley Feng, Annika VanOosbree, John Slunecka, John Lee, Casey B. Williams   +10 more
doaj   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Temporal adaptations in generic and population-specific quality of life and falls efficacy in men with recent lower-limb amputations [PDF]

, 2013
This study examined the longitudinal changes in generic health-related quality of life (QOL), prosthesis-related QOL, falls efficacy, and walking speed in men with lower-limb amputations up to 6 months following discharge from rehabilitation.
Barnett, CT, Polman, RCJ, Vanicek, N
core   +2 more sources

Efficacy of Prompt Initiation of Antiretroviral Therapy in the Treatment of Hemophagocytic Lymphohistiocytosis Triggered by Uncontrolled Human Immunodeficiency Virus

Case Reports in Critical Care, 2017
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening, rapidly progressive hematologic disorder involving uncontrolled immune system activation.
Bryan P. Fitzgerald, Amy L. Wojciechowski, Rajinder P. S. Bajwa   +2 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Asymptotic safety within on-shell perturbation theory

Journal of High Energy Physics
We investigate the renormalisation of Einstein gravity using a novel subtraction scheme in dimensional regularisation. The one-loop beta function for Newton’s constant receives contributions from poles in even dimensions and can be mapped to the beta ...
Kevin Falls, Renata Ferrero
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Developing A Digital Twin of a TRUEX Extraction Process that Enables Non-proliferation and Safeguards Monitoring through Optical Spectroscopy and Machine Learning [version 1; peer review: 1 approved, 2 approved with reservations]

Nuclear Science and Technology Open Research
Background The recycling of spent fuel can increase the longevity and decrease the waste footprint associated with the nuclear fuel cycle. However, nuclear fuel reprocessing introduces the risk of proliferation of fissile material.
Justin T. Cooper, Ramedy Flores, Addyson Barnes, Eduardo Trevino, Kathrine Jesse, Kolton Heaps, Adam J. Pluth, Ashley Shields, Jaren Brownlee   +8 more
doaj   +1 more source

Effect of iron-binding polypeptides and non-starch polysaccharides supplementation on growth performance and fecal scores of weaning pigs

Revista Colombiana de Ciencias Pecuarias, 2022
Background: Weaning is the most stressful event in pig’s life, resulting in postweaning diarrhea and growth retardation. The supplementation of Advanced Digestion Enhancing Protein Plus Technology (ADEPPTTM), which contains iron-binding polypeptides and ...
Jamil Talukder, Clare F Mclnerney, Kathryn L Nelson, Baylee C Close, Ajay K Srivastava, Young D Jang   +5 more
doaj   +1 more source

Von Fall zu Fall [PDF]

International Journal of Practical Theology, 2019
Abstract In 2016, the Dutch Case Studies Project in Chaplaincy Care (CSP) was launched, an interdenominational and interuniversity empirical research project on case studies from different fields of chaplaincy. The article presents the methodological approach and the procedure of description and evaluation.
Gärtner, Stefan, Körver, Sjaak, Walton, Martin N.   +2 more
openaire   +2 more sources