Results 81 to 90 of about 67,029 (331)

TRIM56 Aggravates Cerebral Ischemia‐Reperfusion Injury via Inhibiting KLF4‐Activated Ferroptosis Signaling

open access: yesAdvanced Science, EarlyView.
This study reveals that the E3 ubiquitin ligase TRIM56 exacerbates neuronal ferroptosis and brain damage by mediating K48‐linked ubiquitination and degradation of KLF4, leading to suppression of the xCT/GSH/GPX4 axis. Targeting TRIM56 alleviates cerebral ischemia‐reperfusion injury in vivo and in vitro, highlighting its therapeutic potential.
Qiangping Wang   +15 more
wiley   +1 more source

Fast Sequence Component Analysis for Attack Detection in Synchrophasor Networks [PDF]

open access: yes, 2015
Modern power systems have begun integrating synchrophasor technologies into part of daily operations. Given the amount of solutions offered and the maturity rate of application development it is not a matter of "if" but a matter of "when" in regards to ...
Barella, Richard   +6 more
core   +2 more sources

HRS Degradation‐Induced Nicotinamide Deficiency in Placental Extracellular Vesicles Triggers Preeclampsia by Disrupting Maternal‐Fetal Immune Homeostasis

open access: yesAdvanced Science, EarlyView.
This study shows that lower NAM levels in PE‐derived pEVs correlate with disease severity. NAM‐deficient pEVs reduce Th1 and Th17 inhibition, leading to PE‐like symptoms. NAM in pEVs inhibits Th1 via SIRT1 and Th17 via macrophages. Reduced NAM in PE‐EVs is due to decreased HRS expression in trophoblasts, resulting from elevated HSP27.
Haiyi Fei   +10 more
wiley   +1 more source

Cybersecurity in Smart Grids: Detecting False Data Injection Attacks Utilizing Supervised Machine Learning Techniques

open access: yesEnergies
By integrating advanced technologies and data-driven systems in smart grids, there has been a significant revolution in the energy distribution sector, bringing a new era of efficiency and sustainability.
Anwer Shees, Mohd Tariq, Arif I. Sarwat
doaj   +1 more source

A Novel Data Analytical Approach for False Data Injection Cyber-Physical Attack Mitigation in Smart Grids

open access: yesIEEE Access, 2017
False data injection cyber-physical threat is a typical integrity attack in modern smart grids. These days, data analytical methods have been employed to mitigate false data injection attacks (FDIAs), especially when large scale smart grids generate huge
Yi Wang   +3 more
doaj   +1 more source

Safety and Efficacy of Adoptive Transfer of Stem Cell Memory Enriched Virus Specific T Cells against CMV and EBV

open access: yesAdvanced Science, EarlyView.
This study finds that CD8⁺ TSCM cells exhibit superior self‐renewal, differentiation, and antiviral activity. Transcriptome and epigenome analyses highlight MAPK cascade regulation in TSCM cells. In vivo, virus‐specific TSCM cells show enhanced persistence and tumor protection.
Xun‐Hong Cao   +13 more
wiley   +1 more source

ACSL5 Regulates Glucose Metabolism and Chemotherapy Sensitivity in Colorectal Cancer Cells under Glutamine Deficiency

open access: yesAdvanced Science, EarlyView.
Glutamine deprivation triggers ACSL5 upregulation in tumor cells, sustaining their viability via dual metabolic rewiring programs. ACSL5 enhances glycolysis by relieving p53's inhibition of PGAM1 while also sustaining mitochondrial respiration and TCA cycle flux through promoting IDH2 dimerization.
Shuai Tian   +11 more
wiley   +1 more source

Secure State Estimation of DC Microgrid System Under False Data Injection Attack

open access: yesIEEE Access
In DC microgrids, distributed secondary control plays an important role in maintaining power distribution and voltage recovery. However, distributed control architecture is vulnerable to external attacks, especially false data injection (FDI) attacks. To
Jiawei Mao   +4 more
doaj   +1 more source

Risk-Sensitive Filtering under False Data Injection Attacks

open access: yes2024 IEEE International Conference on Multisensor Fusion and Integration for Intelligent Systems (MFI)
Publisher Copyright: © 2024 IEEE.
Kumar Kundan   +2 more
openaire   +2 more sources

The Mitochondrial Guardian α‐Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK‐SARM1‐ULK1 Axis

open access: yesAdvanced Science, EarlyView.
Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao   +36 more
wiley   +1 more source

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