Results 91 to 100 of about 537,576 (336)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Life Claiming Anaphylaxis to Intravenous Ceftriaxone after Negative Skin Test [PDF]

The Indian Anaesthetists' Forum, 2005
Antibiotic prophylaxis before surgical procedures is commonly practiced. Hypersensitivity reactions to antibacterial drugs are most feared complications; which have varying grades of presentation.
Dr. Prashant K, Dr. Girdhar K, Dr. Raktima A, Dr. Gaurav K   +3 more
doaj  

Short‐term outcomes of pregnant women with convalescent COVID‐19 and factors associated with false‐negative polymerase chain reaction test: A prospective cohort study [PDF]

, 2021
Orhan Şahin, Taner Yıldırmak, Serap Karacalar, Emine Aydın, Mehmet Ali Çiftçi, Helin Bağcı, Şükran Yıldırım, Çağdaş Nurettin Emeklioğlu, Burcu Balcı, Simten Genç, Başak Cıngıllıoğlu, Veli Mihmanlı, Asma Khalil, Erkan Kalafat   +13 more
openalex   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Optimization of a viability PCR method for the detection of Listeria monocytogenes in food samples [PDF]

, 2018
Postprint (author's final ...
Agustí Adalid, Gemma, Codony Iglesias, Francesc, Fittipaldi Gustavino, Mariana   +2 more
core   +2 more sources

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Development of rapid, automated diagnostics for infectious disease: advances and challenges [PDF]

, 2009
The last 2 years has seen an exponential rise in the amount of research funding made available for the development of rapid diagnostic devices for infectious agents of medical importance. This review reports on several such projects.
Ince, J, McNally, A
core   +1 more source

Generic qPCR assays for quality control in environmental DNA research

Environmental DNA
Environmental DNA (eDNA) has been widely used for species surveillance. However, the lack of adequate quality control in many eDNA research projects and applications can lead to false‐negative results, greatly affecting biosecurity surveillance and ...
Xiaocheng Zhu, Karen L. Bell, Meaghan L. Rourke, Hanwen Wu, David Gopurenko   +4 more
doaj   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Diagnostic Accuracy of Five Serologic Tests for Strongyloides stercoralis Infection [PDF]

, 2014
Background:The diagnosis of Strongyloides stercoralis (S. stercoralis) infection is hampered by the suboptimal sensitivity of fecal-based tests. Serological methods are believed to be more sensitive, although assessing their accuracy is difficult because
Albonico, Marco, Angheben, Andrea, Bisoffi, Zeno, Bonafini, Stefania, Buonfrate, Dora, Cimino, Rubén Oscar, Gobbo, Maria, Krolewiecki, Alejandro Javier, Mejia, Rojelio, Muñoz, José, Nutman, Thomas B., Requena-Mendez, Ana, Sequi, Marco   +12 more
core   +3 more sources