Results 191 to 200 of about 153,465 (260)

TP53 Loss Elevates NF‐κB‐IFN‐β‐MHC‐Ia Signaling to Promote NK Cell Resistance in Osteosarcoma

Advanced Science, EarlyView.
TP53 loss in a transforming or osteosarcoma cell promotes cytosolic DNA accumulation, activating NF‐κB‐dependent IFN‐β production. Autocrine IFN‐β signaling increases cell‐surface HLA‐Ia expression, strengthens inhibitory KIR signaling in natural killer cells, and thereby enables the affected cell to evade NK cell‐mediated cytotoxicity.
Guihui Qin, Cheung Kwan Yeung, Ye Yi, Dejin Zheng, Miaoman Ye, Chi‐Chong Chio, Jinjie Wu, Siyi Fu, Chu‐Xia Deng, Ren‐He Xu   +9 more
wiley   +1 more source

Rapid Visual Detection of <i>Pythium insidiosum</i> by LAMP-LFD. [PDF]

J Fungi (Basel)
Sridapan T, Jiaranaikulwanich A, Yurayart C, Krajaejun T.   +3 more
europepmc   +1 more source

A Metabolic‐Epigenetic Axis of AARS1/IGF2BP3‐K280 Lactylation Sustains Endometrial Cancer Stemness and Recurrence

Advanced Science, EarlyView.
Lactate‐driven endometrial cancer relapse is mediated by enzymatic protein modification. Elevated lactate levels activate AARS1, which catalyzes K280 lactylation of IGF2BP3, therefore stabilizing HMGA2 mRNA and promoting tumor stemness and recurrence.
Peng Jiang, Yunfeng Zheng, Chenfan Tian, Yuan Tu, Xiaoxia Chang, Jiaxin Yu, Hangkun Yu, Chunxia Gong, Jie Xiong, Philip N. Baker, Yong Fu, Chao Tong   +11 more
wiley   +1 more source

Advanced MR Technique for the Prediction of a Complete Response Following Neoadjuvant Chemoradiotherapy in Patients with Locally Advanced Rectal Cancer: A Comparative Study Between DWI <i>b</i>2000 and <i>b</i>1000. [PDF]

J Pers Med
Lee G, Kim SH, Kim M, Kim D, Kim HR.
europepmc   +1 more source

Nuclear IDH3A Drives Transcriptional Programs in Melanoma via the YBX1–JUN/FOS Axis

Advanced Science, EarlyView.
Genomic amplification drives aberrant nuclear localization of IDH3A in melanoma. Independent of its canonical metabolic activity, nuclear IDH3A cooperates with YBX1 to activate the c‐JUN/c‐FOS transcriptional program, while NONO facilitates its nuclear localization.
Juan Ran, Yanchun Fang, Shengming Ruan, Juling Wang, Songbai Liu, Yuan Mao, Dongsheng Hou, Yanping Wang, Zi Ye, Qiong Li, Daoxiang Zhang   +10 more
wiley   +1 more source

Perioperative Anaphylactic Shock Induced by Cisatracurium: A Case Demonstrating the Diagnostic and Clinical Value of Early Skin Testing. [PDF]

Am J Case Rep
Ying Y, Tian S, Chen J, Wang K, Li S.
europepmc   +1 more source

Transposable Element Dynamics Drive the Genomic Evolution and Phenotypic Diversification of Allotetraploid Common Carp

Advanced Science, EarlyView.
By integrating 516 whole‐genome resequencing datasets and 236 transcriptomes of allotetraploid common carp, this study establishes the first population‐scale atlas of transposable element (TE) variation in teleost species. TE bursts, relaxed purifying selection, and lineage‐specific loss of ancient insertions shape genome evolution and phenotypic ...
Shuimu Hu, Zhou Jiang, Lin Chen, Gowena Ling Yi Goh, Weijing Li, Qian He, Xintong Chen, Rui Li, Yuxuan Liu, Ning Li, Tao Zhou, Peng Xu   +11 more
wiley   +1 more source

IrregulAB: An open-source rule-based engine for automated red cell antibody panel interpretation. [PDF]

Transfusion
Crucitti D, Ballester VV, Fernández JG, Mellid EF, Perdomo ALR, Míguez CP, Orgueira AM.   +6 more
europepmc   +1 more source

Comparison of diagnostic performance between the World Health Organization and the Centers for Disease Control and Prevention real-time PCR assays for molecular detection of the mpox virus. [PDF]

Microbiol Spectr
Paredes-Núñez D, Salgado S, Sánchez M, Echevarría J, Parrales J, Tinizaray A, Salcedo Maldonado AB, Orlando SA, Garcia Bereguiain MA.   +8 more
europepmc   +1 more source