Results 51 to 60 of about 5,583,624 (329)

Successful identification of culprit drugs of perioperative anaphylaxis by repeated skin testing after negative first skin tests in a patient with a long distant history of perioperative anaphylaxis

Heliyon, 2021
Background: Perioperative anaphylaxis is a severe immediate hypersensitivity reaction to drugs administered in immediate temporal association to surgical procedures. The European Academy of Allergy and Clinical Immunology recommends allergologic tests be
Wasurat Sungworn, Orathai Theankeaw, Aree Jameekornrak Taweechue, Chamard Wongsa, Torpong Thongngarm, Mongkhon Sompornrattanaphan   +5 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Strategy for Controlling Preferential Amplification and Avoiding False Negatives in PCR Typing

BioTechniques, 1996
The use of the PCR method for routine testing has increased dramatically during recent years. Most assays involve coamplification either of an internal control, of several alleles at a given locus or of a variety of bands produced by low-stringency ...
Thomas Weissensteiner, Jerry S. Lanchbury   +1 more
doaj   +1 more source

Colorimetric RT-LAMP SARS-CoV-2 diagnostic sensitivity relies on color interpretation and viral load

Scientific Reports, 2021
The use of RT-LAMP (reverse transcriptase—loop mediated isothermal amplification) has been considered as a promising point-of-care method to diagnose COVID-19.
Mateus Nóbrega Aoki, Bruna de Oliveira Coelho, Luiz Gustavo Bentim Góes, Paola Minoprio, Edison Luiz Durigon, Luis Gustavo Morello, Fabricio Klerynton Marchini, Irina Natassja Riediger, Maria do Carmo Debur, Helder I. Nakaya, Lucas Blanes   +10 more
doaj   +1 more source

Effects of dupilumab treatment on patch test reactions: A retrospective evaluation

Clinical and Experimental Allergy, 2021
Patch test reactions during dupilumab treatment showed a reproducibility rate of 29%. Reproducibility rates were higher for initially extreme (+++) or strong positive (++) reactions.
L. D. de Wijs, J. D. van der Waa, T. Nijsten, J. Silverberg, A. Kunkeler, D. Hijnen   +5 more
semanticscholar   +1 more source

False memory ≠ false memory: DRM errors are unrelated to the misinformation effect [PDF]

, 2013
The DRM method has proved to be a popular and powerful, if controversial, way to study 'false memories'. One reason for the controversy is that the extent to which the DRM effect generalises to other kinds of memory error has been neither satisfactorily ...
Lambert, K., Katie Lambert, Hartmut Blank, Salmon, K., James Ost, Jones, Georgina, Joanna Davies, Ost, James, Davies, J., Georgina Jones, Kelly Salmon, Blank, Hartmut   +11 more
core   +2 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Radiologic–Pathologic Discordance After Image-Guided Breast Biopsy: A Systematic Review of Prevalence and Outcomes

Medical Sciences
Background: Radiologic–pathologic discordance remains an important concern owing to the absence of standardized guidelines. This systematic review aimed to summarize the prevalence of discordant benign outcomes, defined as suspicious imaging findings ...
Pirada Yincharoen, Crystal Pravina Sharma, Weeratian Tawanwongsri   +2 more
doaj   +1 more source

False-Positive Clostridium difficile in Negative-Control Reactions Peak and Then Decrease with Repetitive Refrigeration of Immunoassay [PDF]

International Scholarly Research Notices, 2014
Aberrant false-positive reactions in negative-controls during ELISA testing for Clostridium difficile indicated the potential for false-diagnoses. Experiments with 96-well products showed a maximum peak of false-positive immunoassay reactions with the provided negative-control reagents after 5 refrigeration-to-room temperature cycles (P<0.001 ...
Alexander Rodriguez-Palacios, Henry R. Stämpfli, Yung-Fu Chang   +2 more
openaire   +2 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source