Results 111 to 120 of about 3,555,724 (288)

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Q-Learning Based Equivalent False Target Generation for Multi-Point Source Jamming System

Engineered Science
In the multi-point source jamming (MPSJ) system, the antenna phase error, as an intrinsic issue, seriously affects the distribution of equivalent false targets (EFTs).
Zhihao Cai, Shiqi Xing, Sinong Quan, Xinyuan Su, Junpeng Wang, Weize Meng   +5 more
doaj   +1 more source

GAD65 Antibody ELISA With Extended Reportable Range: Validation and Guidance for Neurological Practice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To (1) validate GAD65‐ELISA detection and quantification for type 1 diabetes mellitus and autoimmune neurological diagnoses, (2) correlate ELISA results (reference range < 5 IU/mL) with established radioimmunoprecipitation assay (RIA; ≤ 0.02 nmol/L), and (3) define ELISA clinical utility and pitfalls.
Andrew McKeon, Dana Olofson, Diana Anissian, Divyanshu Dubey, Eoin P. Flanagan, Max C. Herman, Sarosh R. Irani, Daniel H. Lachance, Maria A. Willrich, Sean Pittock, John R. Mills, Anastasia Zekeridou   +11 more
wiley   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Cause Analysis and Preventive Measures against False Bottoms in Echosounder Data

Applied Sciences
This article presents a summary of three common false-bottom occurrences in echosounder imaging based on an analysis of echosounder data. Utilizing the imaging principle of the echosounder, a comprehensive analysis was conducted and an explanation of ...
Xinquan Xiong, Ruilin He, Wei Fan, Zuli Wu, Shengchi Yu, Zhongqiu Wang, Yongjin Wang, Yang Dai   +7 more
doaj   +1 more source

Added Prognostic Value of EEG Reactivity in Comatose Patients Following Cardiac Arrest

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To evaluate the added prognostic value of EEG reactivity for favorable outcome compared with background analysis during and after targeted temperature management (TTM). Methods Prospective observational cohort study of comatose post–cardiac arrest patients admitted to a single academic center between 2017 and 2022, all undergoing ...
Sarah Caroyer, Marie Obrecht, Charlotte de Maeseneire, Charlotte Damien, Chantal Depondt, Lorenzo Ferlini, Estelle Rikir, Filippo Annoni, Fabio Silvio Taccone, Nicolas Mavroudakis, Benjamin Legros, Nicolas Gaspard   +11 more
wiley   +1 more source

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng, Diego Z. Carvalho, Shahid Karim, Anwar Chahal, Virend K. Somers   +4 more
wiley   +1 more source

A nap before retrieval reduces false identifications in target absent lineups

Scientific Reports
Eyewitness misidentifications are a major cause of wrongful convictions. While most research has focused on the role of sleep in memory encoding and consolidation, recent findings suggest that non-REM sleep may also enhance retrieval processes by ...
Matías Bonilla, Cristian García Bauza, Cecilia Forcato   +2 more
doaj   +1 more source

A Sonar Image Target Detection Method with Low False Alarm Rate Based on Self-Trained YOLO11 Model

水下无人系统学报
Autonomous detection of sonar image targets is a key technology for unmanned undersea systems, but it faces the challenge of high false alarm rates in practical applications, which limits the quality and efficiency of mission execution by unmanned ...
Jingqi HAN, Mingxing NAN, Peng ZHANG, Jiajie CHEN, Zhengliang HU   +4 more
doaj   +1 more source

An Economic Analysis of “False-labeling” [PDF]

, 2003
The purpose of this article is to investigate “false-labeling”. This was revealed at the beginning of 2002. Some Japanese meat packers deceived consumers by labeling imported beef as Japanese beef.
大倉, 真人
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