Results 71 to 80 of about 2,525 (238)

Metabolomic Study of 7-Ethyl-9-(N-methyl)aminomethyl-10-hydroxycamptothecin Derivative (NMe)—The Chemotherapeutic Drug Candidate Versus Irinotecan (IR) on a Mouse Model

Metabolites
Background: In this study, we aimed to compare metabolomic profiles, biodistribution, and detoxification patterns of the novel SN-38 derivative NMe with irinotecan (IR), and to identify NMe-specific metabolites to evaluate its preclinical pharmacokinetic
Piotr Surynt, Beata Naumczuk, Magdalena Popławska, Magdalena Urbanowicz, Katarzyna Unrug-Bielawska, Magdalena Cybulska-Lubak, Zuzanna Sadowska-Markiewicz, Jerzy Sitkowski, Elżbieta Bednarek, Natalia Zeber-Lubecka, Lech Kozerski, Michał Mikula, Jerzy Ostrowski   +12 more
doaj   +1 more source

Substandard, falsified and unregistered medicines in Latin America, 2017-2018

Revista Panamericana de Salud Pública, 2020
Objective. To assess all the incidents of substandard, falsified and unregistered medicines in 2017 and 2018 in Latin America, determining the types of products affected, stages of the supply chain in which incidents were detected, quality deviations ...
Robin Rojas-Cortés
doaj   +1 more source

Cardiovascular and neuropsychiatric outcomes with PCSK9 inhibitors in atherosclerotic cardiovascular disease: A retrospective cohort study

British Journal of Clinical Pharmacology, EarlyView.
Study design and main findings. After 1:1 propensity score matching, 60 885 PCSK9 inhibitor users and 60 885 statin‐only users with ASCVD were compared. Kaplan–Meier curves show 12‐month cumulative event‐free survival for MACE, psychiatric disease, and neurodegenerative disease.
Tianshu Gu, Yang Chen, Nan Zhang, Uazman Alam, Riccardo Proietti, Tong Liu, Kang‐Yin Chen, Gregory Y. H. Lip   +7 more
wiley   +1 more source

Investor Perceptions of Climate Policy: Insights From the US Inflation Reduction Act

Business Strategy and the Environment, EarlyView.
ABSTRACT This paper provides the first event study evidence on how the Inflation Reduction Act's (IRA) dedicated climate provisions reshaped equity valuations in the US carbon‐intensive sectors. Focusing on environmentally sensitive industries (ESI), we analyze cumulative abnormal returns around the four key IRA milestones in 2022–2023.
Laura Ferraro, Arati Kale, Devendra Kale, Franco Ernesto Rubino   +3 more
wiley   +1 more source

A cross-sectional analysis of falsified, counterfeit and substandard medicines in a low-middle income country

BMC Public Health, 2020
Background High prevalence of falsified, counterfeit and substandard medicines pose a threat to public health and treatment failure. This study aimed to investigate the quality of selected essential medicines available in Mongolia.
Daariimaa Khurelbat, Gereltuya Dorj, Bruce Sunderland, Tsetsegmaa Sanjjav, Enkhtuul Bayarsaikhan, Davaadagva Damdinjav, Gantuya Dorj, Altantuya Jigjidsuren, Oyun Lkhagvasuren, Baasandorj Erdenetsetseg   +9 more
doaj   +1 more source

Implementing the EU Falsified Medicines Directive [PDF]

Prescriber, 2019
The European Union's Falsified Medicines Directive, which came into force on 9 February, has laid down rigorous rules for pharmaceutical companies and pharmacists to follow in a bid to eradicate the pernicious impact of fake drugs infiltrating the legal supply chain. Joy Ogden reports on the progress so far.
openaire   +1 more source

How to achieve international action on falsified and substandard medicines [PDF]

BMJ, 2012
Substandard and falsified medicines kill patients, yet progress on the twin challenges of safeguarding the quality of genuine medicine and criminalising falsified ones has been held back by controversy over intellectual property rights and confusion over terms.
Attaran, A, Barry, D, Basheer, S, Bate, R, Benton, D, Chauvin, J, Garrett, L, Kickbusch, I, Kohler, J, Midha, K, Newton, P, Nishtar, S, Orhii, P, McKee, M   +13 more
openaire   +4 more sources

FALSIFICATION OF MEDICINES AND DISTRIBUTION OF FALSIFIED MEDICINES IN UKRAINE: CRIMINALISTIC MEANS OF DETECTION AND COUNTERACTION

Wiadomości Lekarskie, 2021
The aim: To formulate criminalistic recommendations to increase the effectiveness of combating falsification and contribution of falsified medicines. To accomplish analyze of the current state and trends in combating this criminal offense, to create the basis of criminalistic characteristics and methods of their investigation, taking into account the ...
Viktor M, Shevchuk, Ihor V, Parfylo, Mykyta O, Sokolenko   +2 more
openaire   +2 more sources

Weather Action: A Study on the Industry Peer Effects of Corporate Climate Risk Information Disclosure

Business Strategy and the Environment, EarlyView.
ABSTRACT Global climate change has elevated the strategic importance of corporate climate risk disclosure, yet the role of industry peer effects in shaping such disclosure remains underexplored. Grounded in social learning theory, this study proposes an “observation–imitation–reinforcement” framework and empirically tests it using panel data on Chinese
Huer Shuang, Shenghua Lou, Renjie Luo, Jiajia Luo   +3 more
wiley   +1 more source

Combating falsified medicines in Africa through digital artefacts [PDF]

, 2016
Falsified medicines are again in the news, this time in a piece for the BBC News’ websites business section. In his article, Matthew Wall looks at the problem of combating falsified, counterfeit and substandard anti-malarial medicines in Africa through ...
Hibberd, Ralph
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