Results 211 to 220 of about 1,064,760 (292)

Enhancing Molecular Diagnostic Accuracy in Genetic Eye Disorders Through a Personalized Re-Evaluation Strategy. [PDF]

Invest Ophthalmol Vis Sci
Martins PM, Figueiredo I, Cruz N, Gaspar BR, Silva R, Carvalho AL, Marques JP.   +6 more
europepmc   +1 more source

Childlessness and norms of familial responsibility in the Netherlands. [PDF]

, 2011
Dykstra, P.A. (Pearl), Keizer, R. (Renske), Poortman, A-R. (Anne-Rigt)   +2 more
core  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Frequent and clinically relevant germline DNA repair gene variants in young and familial myeloproliferative neoplasms. [PDF]

Blood Cancer J
Meyer R, Rodriguez MJ, Caduc M, Kricheldorf K, Begemann M, Kraft F, Spier I, Dey D, Güzel N, Becker K, Baumeister J, S de Toledo MA, Isfort S, Germing U, Aretz S, Brümmendorf TH, Kurth I, Elbracht M, Teichmann LL, Koschmieder S.   +19 more
europepmc   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Antifibrotic therapy in familial idiopathic pulmonary fibrosis: a comparative cohort study. [PDF]

Sci Rep
Morikawa K, Suzuki Y, Kato S, Kono M, Hashimoto D, Yokomura K, Inoue Y, Yasui H, Hozumi H, Karayama M, Furuhashi K, Enomoto N, Fujisawa T, Inui N, Suda T.   +14 more
europepmc   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Pathogenic variants in affected and unaffected individuals from Indonesian familial cancer: a multigene panel analysis. [PDF]

Sci Rep
Muniroh M, Prihharsanti CHN, Limijadi EKS, Prajoko YW, Ichzana Y, Nabila Z, Setyawati P, Sutrisno RT, Teguh E, Utomo ARH.   +9 more
europepmc   +1 more source

The "Family" in Family Physician [PDF]

The Primary Care Companion For CNS Disorders, 2000
openaire   +2 more sources

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source