Results 191 to 200 of about 2,565,548 (299)

Who Benefited Most? Identifying Parent-Child Dyads With Improved Weight Outcomes in the Feel4Diabetes Study. [PDF]

Pediatr Obes
Vitoratou DI, Karaglani E, Argyropoulou M, Dimakopoulou K, Iotova V, Bazdarska Y, Tankova T, Cardon G, Moreno LA, Rurik I, Torzsa P, Lindström J, Makrilakis K, Manios Y.   +13 more
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Empowering Patients and Families Across the Continuum of Care: From Early Risk Detection to Integrated Home Healthcare and Hospital-at-Home Models. [PDF]

J Nurs Res
Chien LY.
europepmc   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Increasing Interpreter Use for Pediatric Cardiology Units: A Quality Improvement Initiative. [PDF]

Pediatr Qual Saf
Ovalle Sanchez DME, Gauntt J, Porterfield R, Gajarski RJ.   +3 more
europepmc   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

"Quadrupling" the protein family space with global metagenomics. [PDF]

Nucleic Acids Res
Aplakidou E, Baltoumas FA, Chasapi MN, Lamari E, Chasapi IN, Georgakopoulos-Soares I, Karatzas E, Iliopoulos I, Aydin Buluç, Finn RD, Camargo AP, Kyrpides NC, Pavlopoulos GA.   +12 more
europepmc   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

The asymmetric relationship of parental psychological flexibility and parenting involvement in autism: anxiety as a mediator. [PDF]

Front Public Health
Liu J, Chen Z, Li J, Liu D, Wei X.
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source