Results 71 to 80 of about 776,083 (234)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Effectiveness of family support-based companion video sharing to improve depression in perinatal maternity: a randomized controlled trial study protocol

Frontiers in Psychiatry
BackgroundThe importance of family support in addressing maternal anxiety and depression during pregnancy is widely recognized. However, cultural nuances and healthcare system dynamics in China call for tailored interventions for perinatal mental health.
Rantong Bao, Chenxin Yang, Ruijin Zhu, Wenzhuo Li, Yang Bai, Yang Jiang, Guoying Zhang   +6 more
doaj   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Effectiveness of implementing family involvement on patient outcomes in individuals with psychotic disorders: a pragmatic cluster randomised controlled trial

BMC Psychiatry
Background The purpose of this sub-study, as part of the Implementation of guidelines on Family Involvement for persons with Psychotic disorders (IFIP) trial, was to examine the effectiveness of family interventions (FIs) implemented through an ...
Irene Norheim, Reidar Pedersen, Maria Lie Selle, Jan Ivar Røssberg, Lars Hestmark, Kristin Sverdvik Heiervang, Torleif Ruud, Vilde Maria Åsholt, Kristiane Myckland Hansson, Paul Møller, Roar Fosse, Solveig Helene Høymork Kjus, Maria Romøren   +12 more
doaj   +1 more source

Implementation of guidelines on Family Involvement for persons with Psychotic disorders: a pragmatic cluster randomized trial. Effect on relatives’ outcomes and family interventions received

Frontiers in Psychiatry
BackgroundFamily interventions (FI) are recommended as part of the treatment for psychotic disorders, but the implementation in mental health services is generally poor.
Irene Norheim, Reidar Pedersen, Maria Lie Selle, Jan Ivar Røssberg, Jan Ivar Røssberg, Lars Hestmark, Kristin Sverdvik Heiervang, Kristin Sverdvik Heiervang, Torleif Ruud, Torleif Ruud, Vilde Maria Åsholt, Kristiane Myckland Hansson, Paul Møller, Roar Fosse, Maria Romøren   +14 more
doaj   +1 more source

Familias con Orgullo: Study protocol for an efficacy study of a family-based intervention for Hispanic sexual minority youth. [PDF]

PLoS One, 2023
Lozano A, Estrada Y, Scott D, Tapia MI, Santos HP, Carrico AW, Zolobczuk J, Manker A, Prado G.   +8 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Promoting healthy sleep in Chinese kindergarteners through a family-based intervention: protocol of the "Healthy Sleep" randomised controlled trial. [PDF]

BMC Public Health, 2023
Zhang Z, Li L, Li X, Okely A.
europepmc   +1 more source