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The words of prevention, part II: ten terms in the realm of quaternary prevention
Revista Brasileira de Medicina de Família e Comunidade, 2015 Objective: This part II article about the ‘words of prevention’ presents in a terminological way the content of ten current concepts used in the prevention domain which are closely linked to quaternary prevention: (1) overinformation, (2) overdiagnosis, (
Marc Jamoulle +6 more
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Неходжкінська лімфома в практиці сімейного лікаря (клінічне спостереження) [PDF]
, 2018 Представлено клиническое наблюдение по проблеме установления онкологического диагноза семейным врачом, маршрута направления к врачу-онкологу для проведения специфического лечения с последующей работой в бригадной команде и медицинским сопровождением в ...
Василевська, І.В.
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Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Construction of Evaluation Index System Inter-professional Collaboration in Family Doctor Team [PDF]
Zhongguo quanke yixueBackground Implementing effective inter-professional collaboration based on family doctor teams is key to meeting the increasingly complex health demands of residents and providing high-quality integrated care. However, there is currently a lack of tools
ZHENG Caiyun, WU Shuanger, YU Ganquan, WANG Xin
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Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Indian Journal of Physiology and Pharmacology, 2021 Ramji Singh, Pramita Dubey
openaire +2 more sources
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
, 2013 A 33 year old primagravida rhesus positive woman was referred to the Emergency Department by her family doctor at 27 weeks gestation. At 25 weeks of gestation, she had been diagnosed with hypertension and was started on labetalol therapy.
Bugeja, Roberta, Galdes, Caroline
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Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Journal of Fasa University of Medical Sciences, 2012 Background and Objective: Health care systems in different countries are organized to provide services, including prevention, treatment, and rehabilitation of people, and they are influenced by political, economic, and cultural factors. Health and safety
Jalil Azizi +2 more
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