Results 111 to 120 of about 4,459,067 (295)
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Book review: young British muslims: identity, culture, politics and the media [PDF]
, 2012 In Britain’s highly politicised social climate in the aftermath of the 7/7 London bombings, this book provides an in-depth understanding of British Muslim identity through migration history, family settlement, socio-economic status, religion and culture,
Sandberg, Russell
core
P/2006 VW139: A Main-Belt Comet Born in an Asteroid Collision?
, 2012 In this paper we apply different methods to examine the possibility that a small group of 24 asteroids dynamically linked to main-belt comet P/2006 VW139, recently discovered by the Pan-STARRS1 survey telescope, shares a common physical origin.
Alberto Cellino +69 more
core +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Officer-Involved Domestic Violence: The Mediating Factors [PDF]
, 2018 Domestic and family violence has been a critical issue in contemporary society. Efforts have been made in researching the causes, effects, and mediating factors of domestic violence in relation to the workplace.
Baron, Isaac
core +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
The impact of sex-selective abortion technology on the evolution of postnatal gender-bias conventions [PDF]
A substantial body of research presents the absence of control on the family sex-composition as one of the main reasons for raising neglected young girls in context of rooted son preference.
Rebeca A. Echávarri
core
The effective strength of selection in random environment
, 2020 We analyse a family of two-types Wright-Fisher models with selection in a random environment and skewed offspring distribution. We provide a calculable criterion to quantify the impact of different shapes of selection on the fate of the weakest allele ...
Casanova, Adrián González +2 more
core