Results 51 to 60 of about 9,019,681 (254)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Journal of the Malta College of Family Doctors : volume 5 : issue 3 [PDF]

, 2016
MALLIA, P. - Graduation, specialisation and future initiatives -- GRECH, A., AXIAK, S., & GERADA, C. - The interphase between family medicine and mental health -- PULLICINO, G., PAVIA, J., ZINTILIS, S., FRANCALANZA, S., SCIORTINO, P., & SCIORTINO, P. -
Mallia, Pierre, Malta College of Family Doctors   +1 more
core  

The Roles of Need for Achievement and Family Environment in Stimulating Entrepreneurial Interest through Self-Efficacy

Jurnal Economia, 2020
: This study was designed to reveal the extent to which the need for achievement and family environment affected entrepreneurial interest through self-efficacy, either directly or indirectly.
Fiarika Dwi Utari, Sukidjo Sukidjo
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

INCIDENCIA Y FACTORES RELACIONADOS CON EL SÍNDROME CLIMATÉRICO EN UNA POBLACIÓN DE MUJERES MEXICANAS

Revista Chilena de Obstetricia y Ginecología, 2007
Objetivo: Determinar las características del entorno familiar y actitud frente a la menopausia y su influencia en el síndrome climatérico. Métodos: Estudio comparativo en mujeres con menopausia que acudieron como acompañantes a las Unidades de Medicina ...
Genaro Vega M, Adrián Hernández L, Guillermo Leo A, Jesús Vega M, Minerva Escartin Ch, Javier Luengas M, María Guadalupe Guerrero L   +6 more
doaj  

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Development of eating behavior: the way from infancy to adolescence. Review of foreign studies

Клиническая и специальная психология, 2016
Studies examining development of eating behavior in different age groups are reviewed. Determinants of disordered eating attitudes from infancy to adolescent are particularly examined. Family environment and social context are general factors. Knowledge,
Durneva M.U.
doaj  

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Secondhand Smoke Exposure and Brain Health Indicators in Cuban Preschoolers

Toxics
Secondhand smoke affects nearly 40% of children worldwide, leading to serious health and behavioral problems. Being neurotoxic, it poses potential risks for child health and learning.
Yaser Ramírez Benítez, Miriela Díaz Bringas, Rodneys Mauricio Jiménez-Morales, Ijang Bih Ngyah-Etchutambe, Linda S. Pagani   +4 more
doaj   +1 more source