ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan +9 more
wiley +1 more source
Gender composition of board of directors in Spanish family firms and its influence on corporate’s risk preferences Resumen Basándonos en la premisa de la inclinación de las empresas familiares hacia el objetivo de la preservación del negocio, en ...
Mercedes Redondo-Cristóbal +1 more
doaj
Successor-related factors are among the most discussed topic in family firm succession. The purpose of this study is to explore successor-related factors associated with effective intra-family succession among successors.
Aprihatiningrum Hidayati +3 more
doaj +1 more source
Impact of the ‘Family-firm life cycle’ on the Management Processes Involved in Sustainable Glasshouse Horticulture [PDF]
In Flanders glasshouse vegetables and ornamental plants are typically produced at family businesses. At this type of businesses the objectives and long-term firm developments are influenced by the so called ‘family-firm life cycle’.
Taragola, Nicole +2 more
core +1 more source
RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu +21 more
wiley +1 more source
It's a Family Affair: A Case for Consistency in Family Foundation Giving and Family Firm Community CSR Activity. [PDF]
Cruz C, Milanov H, Klein J.
europepmc +1 more source
Founding Family Ownership and Firm Performance: Empirical Evidence From Consumer Goods Industry in Indonesia [PDF]
This research investigates the significant influence of family ownership on firm performance in order to provide information to decision makers and other interested parties. The analysis includes comparisons between family and non-family firm performance
Bambang, M. (Margareta) +1 more
core
ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio +8 more
wiley +1 more source
Loss of control vs. risk reduction: decision factors for hiring non-family CFOs in family firms [PDF]
Objectives: We examine decision factors of family firm owners for hiring a non-family Chief Financial Officer (CFO). We explore the perceptions of family firm owners towards external managers by analyzing how their family-specific and company-specific ...
Achleitner, Ann-Kristin +2 more
core
Family management and firm performance in family SMEs: the mediating roles of management control systems and technological innovation [PDF]
The aim of this research is to analyze the mediating role of the use of management control systems (MCS) and the achievement of technological innovation (TI) in the relationship between family management and firm performance in family small and medium ...
Anderson +24 more
core +3 more sources

