Results 91 to 100 of about 7,998,250 (290)

Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis

Advanced Science, EarlyView.
Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang, Jianhua Li, Huilu Zhang, Qi Qin, Yichen Huang, Xiaofan Tian, Chao Sun, Binbin Li, Zhengxin Wang, Xin Zhang   +9 more
wiley   +1 more source

Copper‐Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF‐α/ATP7A Axis

Advanced Science, EarlyView.
This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao, Yongzhe Hao, Ziqi Ding, Zhipeng Wang, Yujia Shi, Yanhua Huang, Chunjian Qi, Qian Zhang   +7 more
wiley   +1 more source

Today’s Peasant and Information and Communication Technology

Ekonomski Vjesnik, 2010
The society and technology determine, by their specificities, the culture of an epoch, of an area and of the people that inhabit it. The modernity is primarily determined by I.C.T. so that the society is often called information society and culture the
Antun Šundalić, Josip Mesarić, Željko Pavić   +2 more
doaj  

Cultural dimension of Indian family firms – impact on successor selection

Problems and Perspectives in Management, 2015
India is one of the fastest growing economies and becoming a key player in the global business arena. The Indian economic landscape is dominated by family firms which range from small corner shops to global diversified conglomerates. A large majority of these firms are fast approaching the critical stage of succession.
Bañegil Palacios, Tomás M., Jorge, Sílvia Ferreira, Jayantilal, Shital   +2 more
openaire   +2 more sources

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

Distribution of Lithuanian publications by J. Zavadzkis firm 1805-1864

Knygotyra
J. Zavadzkis' firm—one of the largest printing, publishing, and distributing firms in Lithuania—was the most important enterprise in the publishing and trade of Lithuanian books in the 19th century.
Aušra Navickienė
doaj   +3 more sources

Private equity minority investments in large family firms: what influences the attitude of family firm owners? [PDF]

This paper extends research in the field of private equity investments in family firms. It contributes to the literature by fundamentally analyzing the decision criteria of family firm owners for using minority investments of private equity investors ...
Schraml, Stephanie, Achleitner, Ann-Kristin, Tappeiner, Florian   +2 more
core  

Integrating Ecology and Economics in Agent‐Based Models to Support Agricultural Policy

Advanced Science, EarlyView.
Agent‐based models are valuable tools for studying social‐ecological systems in agriculture. This review maps how existing agent‐based models represent the human and natural domains of agriculture, and discusses developments in economic and ecological agent‐based modeling.
Daniel Vedder, Judith Josephin Rakowski, Lea‐Deborah Kolb, Greta Sophie Theilen‐Loges, Sebastian Lakner, Guy Pe'er   +5 more
wiley   +1 more source

Family firm governance and the “logic of the market”: The role of culture

, 2022
Institutional theory suggests that family firms, especially those that are listed, are forced to conform to the “logic of the market” in order to enhance their legitimacy in front of stakeholders. However, prior research has considered market logic as unique, omitting to consider that for the purposes of defining the logic of market, the cultural ...
Michele Pinelli, Francesco Debellis
openaire   +1 more source

An Adipocyte MKK3–p38β Axis Preserves Insulin Responsiveness in Mice and Is Reciprocally Altered in Human Obesity

Advanced Science, EarlyView.
The adipocyte MKK3–p38β axis emerges as an adaptive stress‐response pathway during obesity. Human visceral adipose tissue analyses, adipocyte‐specific mouse models, and primary adipocytes show that the MKK3–p38β axis supports insulin responsiveness by restraining p70S6K‐dependent inhibitory IRS1 feedback and preserving AKT–GLUT4 signaling. This pathway
Edgar Bernardo, Nuria Matesanz, Jorge‐Luis Torres, Alba C. Arcones, Juan Ignacio Jiménez‐Loygorri, Alfonso Mora, Leticia Herrera‐Melle, Luis Leiva‐Vega, Maria Elena Rodriguez, Lourdes Hernández‐Cosido, Marta Leon, Paula Yong González, Teresa Durán, Tamara Parracho, Francisca Mulero, Rubén Nogueiras, J. Simon C. Arthur, Angel R. Nebreda, Roger J. Davis, Miguel Marcos, Guadalupe Sabio   +20 more
wiley   +1 more source