Results 91 to 100 of about 3,774 (250)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The religious attitude within psychological hardiness attachment styles among students who appeal for divorce

Journal of Holistic Nursing and Midwifery, 2016
Introduction: Family is the most important establishment according Islamic religion. On the other hand, life attachment styles could effect on quality of family establishment and marriage.
Bahman Akbari
doaj  

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Concept Analysis of Health-related Hardiness in Older People with Multiple Diseases Using a Hybrid Model

Journal of Mazandaran University of Medical Sciences, 2020
Background and purpose: Patients with hardiness personality could better control the psychological distress induced by multiple diseases. The present study aimed to clarify the concept of health related hardiness in older individuals with multiple ...
Fatemeh Ghaffari, Zahra Fotokian, Zahra Jannat alipoor   +2 more
doaj  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

ADAPTATION OF THE FAMILY HARDINESS INDEX (FHI) INSTRUMENT FOR INDONESIAN ADOLESCENTS

Jurnal Ilmu Keluarga dan Konsumen
Family resilience in adolescence measures the ability to cope with challenges and disruptions within the family and engage in positive adaptation in their role as children. To address the limitations of the availability of family resilience measurement tools in the Indonesian language, this study aims to adapt and test the reliability and validity ...
Luisa Erica, Sri Redatin Retno Pudjiati
openaire   +3 more sources

THE UNTOLD STORY OF HAVING A FAMILY MEMBER AS TERROR CONVICT: STUDY OF FAMILY HARDINESS & FAMILY PERSPECTIVE

Jurnal Psikologi
Families with members charged for terrorism face immense challenges. This study aims to understand family hardiness and family perspective of families who have family members as terrorists convict. Using a phenomenological approach, we explore family perspectives and family hardiness in three informants (father,mother, older sister of a terror convict).
Sabiqotul Husna, Muslim Hidayat
openaire   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source