Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Injury Patterns in Soccer-Induced Maxillofacial Fractures and Ocular Trauma: A Narrative Review
Background Maxillofacial fractures and ocular trauma are significant injuries in soccer, with potential functional, aesthetic, and visual consequences if unrecognized. Few reviews have specifically examined both injury patterns in this sport. The purpose
Anaas M. Mergoum +5 more
doaj +1 more source
PERCEPTIONS OF THE HEALTH TEAM AND FAMILY MEMBERS REGARDING THE CHILDCARE CONSULTATION
This qualitative descriptive study aimed to investigate the dynamic of the childcare consultation of Family Health Strategy teams of an Integrated Health Nucleus and reflections of this in the conceptions of the health team and the family members of ...
Tatiana da Silva Melo Malaquias +2 more
doaj +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Member guide: how to use your subsidy to get health insurance
This archived document is maintained by the Oregon State Library as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.OrDocs shipping list 2010-27Title from cover"Updated October
core +2 more sources
Challenges in mental health care in the Family Health Strategy [PDF]
Objective: To discuss the practice of mental health care performed by healthcare professionals from the Family Health Strategy in Fortaleza-CE, Brazil. Methods: This is a critical and reflective study conducted in six Basic Health Units in Fortaleza-Ce ...
Consuelo Helena Aires de Freitas +4 more
doaj
[Different approaches to the family in the context of the family health program/strategy].
Este estudio presenta el escenario que favoreció la inclusión de la familia como foco de atención en las políticas públicas. En el siglo XX, las estrategias para interrumpir el empobrecimiento y la vulnerabilidad de las familias ocurren de manera diferenciada, según los diferentes "Estados de Bienestar", en las sociedades capitalistas. Por consiguiente,
openaire +3 more sources
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Background Pediatric emergency department (ED) visits for mental health are costly and often preventable. Access to primary care and behavioral health providers can improve mental health and reduce unnecessary ED visits.
Jennifer L. Gilbert +14 more
doaj +1 more source

