Results 101 to 110 of about 1,406,007 (316)

Variants in the Upstream Region of the Insulin Receptor Substrate-1 Gene Is Associated with Major Depressive Disorder in the Han Chinese Population

Neuropsychiatric Disease and Treatment, 2020
Fan Wang,1,2 Shunying Yu,3 Rubai Zhou,1 Ruizhi Mao,1 Guoqing Zhao,1,4 Xiaoyun Guo,1 Qingqing Xu,3 Jun Chen,1 Chen Zhang,1 Yiru Fang1,5,6 1Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine ...
Wang F, Yu S, Zhou R, Mao R, Zhao G, Guo X, Xu Q, Chen J, Zhang C, Fang Y   +9 more
doaj  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Lander Family History - Accession 715 no. 109

, 2015
The Lander Family History consists of a history of the Lander family descended from Samuel (1833-1904) and Laura Ann McPherson (1833-1914) of Lincolnton, North Carolina.
Spain, Frances Lander, Family History - Lander Family   +1 more
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Familial Risk for Chronic Disease and Intent to Share Family History With a Health Care Provider Among Urban Appalachian Women, Southwestern Ohio, 2007

Preventing Chronic Disease, 2010
IntroductionFamily history of certain chronic diseases is a risk factor for those diseases. We assessed demographic characteristics associated with familial risk for common diseases and whether familial risk was associated with intent to share family ...
Margaret G. Au, MBE, MS, Sandra J. Cornett, RN, PhD, Todd G. Nick, PhD, Jody Wallace, MS, Yu Wang, MS, Nancy S. Warren, MS, Melanie F. Myers, MS, PhD   +6 more
doaj  

INFLUENCE OF THE FACTOR FAMILY HISTORY ON THE RISK OF CORONARY HEART DISEASE

Евразийский Кардиологический Журнал, 2015
For the purpose of investigating the correlation between incidence of myocardial infarction (MI) and family history of cardiovascular disease (CVD), the study of prevalence of CVD among the first-degree relatives of patients with a known MI episode has ...
J. A. Behbudova
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Prevalence, Clinical Characteristics, and Risk Among Patients with Ischemic Heart Disease in the Young Jordanian Population

Open Access Emergency Medicine, 2020
Liqaa A Raffee,1 Khaled Z Alawneh,2 Rashid K Ibdah,3 Sukaina I Rawashdeh,3 Sohaib Zoghoul,4 Abdel Salam Ewais,1 Abdel-Hameed Al-Mistarehi5 1Department of Accident and Emergency Medicine, Faculty of Medicine, Jordan University of Science and Technology ...
Raffee LA, Alawneh KZ, Ibdah RK, Rawashdeh SI, Zoghoul S, Ewais AS, Al-Mistarehi AH   +6 more
doaj  

Role of One Month Yoga Training on Arterial Stiffness in Young Adults with Familial Hypertension: A Prospective Interventional Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Family history of hypertension is an important non modifiable risk factor that may lead to development of hypertension in otherwise healthy individuals. This is reflected in altered vascular stiffness parameters in these subjects.
Yashwanth Yellanki, Manjunatha R Aithala, Chandini Sheik, Amrit Podder, Madivalappa P Doddamani, Jyoti P Khodnapur   +5 more
doaj   +1 more source