Results 121 to 130 of about 1,406,007 (316)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
, 2008 Genealogical Family Historians conduct research in order to reconstruct genealogical families, through the application of a rigorous methodology: weighing the evidence for placing each individual in a family group, linking family groups of the past and ...
Brown, Margaret Mary Selman
core
Astrocyte heterogeneity in brain metastases
Molecular Oncology, EarlyView.Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver +2 more
wiley +1 more source
Family History Collaborators in Conversation
, 2019 Ashley Barnwell and Laura King converse about their collaborations with family historians in Australia and England. They reveal the potential uses of collaboration when challenging understandings of ‘the family’, decolonizing and declassing historical ...
Barnwell, Ashley
core +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Frequency of Prediabetes, Raised BMI and Low Plasma HDL-Cholesterol in Offspring of Diabetes
Journal of the Dow University of Health Sciences, 2014 Background: World wide approximately 470 millions people are getting affected by a prediabetic state. Risk of diabetes is doubled when there is a family history of diabetes (FHD) in parents.
Meraj Rahim +4 more
doaj
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
A sense of being Italian: the value of family history
, 2009 There has been an upsurge in interest in family history in Australia in recent times, especially since it ceased to be a shameful or embarrassing thing to have convict ancestors.
Dewhirst, Catherine
core
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source