Results 131 to 140 of about 4,871,569 (364)
Evaluation of family history information within clinical documents and adequacy of HL7 clinical statement and clinical genomics family history models for its representation: a case report [PDF]
, 2010 Genevieve B. Melton +5 more
openalex +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Frequency of Prediabetes, Raised BMI and Low Plasma HDL-Cholesterol in Offspring of Diabetes
Journal of the Dow University of Health Sciences, 2014 Background: World wide approximately 470 millions people are getting affected by a prediabetic state. Risk of diabetes is doubled when there is a family history of diabetes (FHD) in parents.
Meraj Rahim +4 more
doaj
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
FEBS Letters, EarlyView.The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber +7 more
wiley +1 more source
Rural Fairfield Property Histories
, 2013 Each lot history give the original lot number, original owner, the current address, the owner of the lot in 1860, a description of the lot or dwelling in 1860, a recital of ownership with as much detail as is known, a comprehensive lot history, any known
Smith, Timothy H.
core
A review of breast cancers found in the Welsh Family History screening programme [PDF]
, 2008 Sally Bolt +4 more
openalex +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source