Results 141 to 150 of about 1,388,888 (219)

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Family History of Chronic Pain: What Impact Does It Have on Current Clinical Status? Results From an Italian Study. [PDF]

Eur J Pain
Pupo S, Barbi C, Incardona MA, Musetti G, Menchetti M, Pelizza L.   +5 more
europepmc   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Early Alterations in Glucose Homeostasis Associated with a Family History of Diabetes Mellitus: A Systematic Review and Meta-Analysis. [PDF]

Med Sci (Basel)
Tobar KDL, Nonato LC, Dilelli LN, Prado AKG, Ghezzi AC, Cambri LT.   +5 more
europepmc   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Apolipoprotein L1 genetic testing, family history of hypertension, and kidney disease in a Midwestern U.S. cohort. [PDF]

Front Nephrol
Lentine KL, Elsurer Afsar R, Clair B, Memon AA, Edwards JC, Miyata KN, Afsar B, Schnitzler M, Xiao H, Carriker A, Abu Al Rub F, Hsu CY, Muiru AN, Freedman BI, Philipneri MD, Caliskan Y.   +15 more
europepmc   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Validation of self-reported family history of myocardial infarction using nationwide health care data. [PDF]

Eur J Epidemiol
Wahrenberg A, Leander K, Häbel H, Magnusson PKE, Kuja-Halkola R, Bergström G, Lind L, Hagström E, Engström G, Jernberg T, Söderberg S, Östgren CJ, Svensson P.   +12 more
europepmc   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Personalized risk estimates of advanced neoplasia development in individuals with a family history of colorectal cancer. [PDF]

Fam Cancer
Greuter MJE, Akwiwu EU, Hennink SD, Bisseling TM, Spanier MBW, German Consortium for Familial Intestinal Cancer, Nagtegaal ID, Canfell K, Dekker E, Klausch T, Lansdorp-Vogelaar I, van Leerdam ME, Hoogerbrugge N, Coupé VMH.   +13 more
europepmc   +1 more source