Results 181 to 190 of about 12,436,746 (396)

Increased family history documentation in internal medicine resident continuity clinic at a community hospital through resident-led structured genetic education program

open access: green, 2022
Jirat Chenbhanich   +7 more
openalex   +2 more sources

Cohabiting unions in France and West Germany [PDF]

open access: yes
This paper compares the non-marital birth pattern in France and West Germany. Since the beginning of the eighties, France witnessed a steady increase in non-marital birth rates, while in West Germany non-marital birth rates have remained at a relatively ...
Jean-Marie Le Goff
core  

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

open access: yesMolecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken   +7 more
wiley   +1 more source

Inherited mutations in 17 breast cancer susceptibility genes among a large triple-negative breast cancer cohort unselected for family history of breast cancer.

open access: yesJournal of Clinical Oncology, 2015
F. Couch   +41 more
semanticscholar   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

The drama of Lermontov M.: congenital disorder of personality or the influence of family history? Opinion of the systemic family therapist and psychiatrist

open access: yesПсихология и Психотерапия Семьи, 2017
The result was the following conclusions: a family history of Mikhail Lermontov observed multiple projective process, the object of which was the poet himself. Lermontov M.Y. from an early age was a member of the extremely pathological triangle involving
Elena Fisun, Grigory Gorshunin
doaj  

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

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