Results 181 to 190 of about 4,871,569 (364)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Hereditary Bilateral Retinoblastoma Detected on Screening in a Two-Month-Old Infant With a Strong Family History. [PDF]

Cureus
Bhola DE, Bhola RM, Dindial K.
europepmc   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Family history of stroke and cardiovascular diseases in early-onset cryptogenic ischaemic stroke. [PDF]

Eur Stroke J
Sihvo MC, Ylikotila P, Zedde M, Pascarella R, Sarkanen T, Jatužis D, Ryliškienė K, von Sarnowski B, Licenik R, Ferdinand P, Kõrv J, Kõrv L, Pezzini A, Fonseca AC, Paula A, Martínez-Sánchez P, Yesilot N, Fromm A, Waje-Andreassen U, Redfors P, Jood K, Huhtakangas J, Sairanen T, Hedman M, Jäkälä P, Ten Cate H, Gerdts E, Lehto M, Sinisalo J, Kittner SJ, Mitchell BD, Lindgren AG, Ilinca A, Putaala J, Tomppo L.   +34 more
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Evaluating the impact of family history and polygenic risk scores on cardiometabolic disease risk. [PDF]

BMC Med
Onyenobi E, Oyibo K, Zhong M, Adebamowo SN.   +3 more
europepmc   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Measuring Muscle Post-Exercise Oxygen Consumption in Individuals with a Family History of Diabetes. [PDF]

J Funct Morphol Kinesiol
McCully KK, Kachappilly O, Flame C, Jain A.   +3 more
europepmc   +1 more source