Results 191 to 200 of about 12,436,746 (396)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Polygenic Risk Score, Parental Socioeconomic Status, Family History of Psychiatric Disorders, and the Risk for Schizophrenia: A Danish Population-Based Study and Meta-analysis.

JAMA psychiatry, 2015
E. Agerbo, P. Sullivan, B. Vilhjálmsson, C. Pedersen, O. Mors, A. Børglum, D. Hougaard, M. Hollegaard, S. Meier, M. Mattheisen, S. Ripke, N. Wray, P. Mortensen   +12 more
semanticscholar   +1 more source

Geography is not Destiny. Geography, Institutions and Literacy in England, 1837-1863 [PDF]

Geography made rural society in the south-east of England unequal. Economies of scale in grain growing created a farmer elite and many landless labourers.
Gregory Clark, Rowena Gray
core  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Tips of family history taking in diagnosing Alport syndrome: a report of six cases. [PDF]

CEN Case Rep
Mori T.
europepmc   +1 more source

Family medicine training and practice in Malawi: History, progress, and the anticipated role of the family physician in the Malawian health system

, 2018
Martha Makwero, Prosper Lutala, Anna McDonald   +2 more
openalex   +2 more sources

Family history and the natural history of colorectal cancer: systematic review

Genetics in Medicine, 2015
P. M. Nora B. Henrikson, MS Elizabeth M. Webber, PhD Katrina A. Goddard, MA Aaron Scrol, PhD Mph Margaret Piper, MD Marc S. Williams, PhD Doris T. Zallen, MD Mph Ned Calonge, MD Theodore G. Ganiats, A. Cecile, MA J.W. Janssens, PhD Ann Zauber, PhD Iris Lansdorp-Vogelaar, MD PhD Marjolein van Ballegooijen, M. M. Evelyn P. Whitlock   +14 more
semanticscholar   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Factors Associated With Self-reported Family History of Pelvic Floor Disorders. [PDF]

Urogynecology (Phila)
Zabriskie HA, Hendrickson WK, Nygaard IE, Swenson CW.   +3 more
europepmc   +1 more source