Results 231 to 240 of about 4,817,785 (305)

Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler, Vivian Maas, Arian Taheri Amin, Jennifer Faber, Tamara Schaprian, Katharina Hill, Matthis Synofzik, Lisa H. Graf, Heike Jacobi, Manuela Lima, Ana F. Ferreira, Bart P. van de Warrenburg, Ilse H. J. Willemse, Dagmar Timmann, Andreas Thieme, Paola Giunti, Hector Garcia‐Moreno, Magda M. Santana, Jeannette Hübener‐Schmid, Elin H. Davies, Thomas Klockgether   +20 more
wiley   +1 more source

Sex-specific differences in brain activity dynamics of youth with a family history of substance use disorder. [PDF]

Nat Ment Health
Schilling L, Singleton SP, Tozlu C, Hédo M, Zhao Q, Pohl KM, Jamison K, Kuceyeski A.   +7 more
europepmc   +1 more source

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

Family history of type 2 diabetes delays development of type 1 diabetes in TEDDY children with islet autoimmunity. [PDF]

Diabetologia
Veijola R, Tamura RN, Clasen JL, Elding Larsson H, Warncke K, Steck AK, Haller MJ, Jonsdottir B, Akolkar B, Hagopian WA, Rewers MJ, She JX, Ziegler AG, Krischer JP, Toppari J, TEDDY Study Group.   +15 more
europepmc   +1 more source

Diffusion Spectrum Imaging Maps Early Axonal Loss and a Unique Progressive Signal in Neuronal Intranuclear Inclusion Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang, Yixiu Pei, Xiaobao Hu, Ying Xiong, Fang Wang, Yanyan Yu, Min Zhu, Dandan Tan, Meihong Zhou, Daojun Hong, Fuqing Zhou   +10 more
wiley   +1 more source

A Comparison of Accommodative Ability in Healthy Controls, Diabetics, and Healthy Subjects with a Family History of Diabetes. [PDF]

Br Ir Orthopt J
Rout S, Radhakrishnan A.
europepmc   +1 more source

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

Incomplete Family History and Meeting Algorithmic Criteria for Genetic Evaluation of Hereditary Cancer.

JAMA Netw Open
Harris A, Bather JR, Bradshaw RL, Kawamoto K, Del Fiol G, Kohlmann WK, Chavez-Yenter D, Monahan R, Chambers RL, Sigireddi M, Goodman MS, Kaphingst KA.   +11 more
europepmc   +1 more source

Mid-childhood developmental and behavioural outcomes in infants with a family history of autism and/or attention deficit hyperactivity disorder. [PDF]

J Child Psychol Psychiatry
Charman T, Bazelmans T, Pasco G, Begum Ali J, Johnson MH, Jones EJH, BASIS/STAARS Team.   +6 more
europepmc   +1 more source