Results 111 to 120 of about 9,139,540 (297)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Best Practices for Early Intervention and Remediation of Residents in Family Medicine: Insights From an Interdisciplinary Delphi Study

Background: Remediation and early intervention for family medicine residents who experience performance problems represent a challenge for programs, faculty, and residents.
Pratt, Grace, Clark, Molly, Fraser, Kathryn, Delbridge, Emilee, Arthur, Melissa, Haymaker, Christopher M., Schilling, Jessica, Cadick, Amber, Romain, Amy   +8 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Are people in Tehran prepared for the family physician program?

International Journal of Preventive Medicine, 2014
Background: Upon successful experiences of family physician program in the rural regions, Iranian Ministry of Health and Medical Education (MOHME) made a decision to expand this program to urban areas.
Azam Majidi, Nina Loori, Khandan Shahandeh, Ensiyeh Jamshidi, Reza Majdzadeh   +4 more
doaj  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Family physician hospitalists: the good and the bad

McGill Journal of Medicine, 2020
A hospitalist is the most responsible physician for inpatient care without the responsibility for care post discharge. In Canada, the majority of hospitalists are family physicians which raises concerns in the context of a shortage of family physicians ...
Satya Rashi Khare
doaj  

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Drop of Indigo Dye

International Journal of Whole Person Care
 I share my story of how an unexpected diagnosis changed my lens in caring for my patients. This story shines a light on how narrative medicine tools employed by various healthcare professionals touch me as a patient, in turn, realizing how it trickled ...
Aisha Husain
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Perception of medical students about family medicine in Karachi, Pakistan: Medical students’ perception about family medicine

Journal of Family Medicine and Primary Care
Objectives: To assess the perceptions of medical students about Family Medicine (FM) as a career choice and to examine if exposure to FM in undergraduate medical curriculum is associated with a positive perception of FM.
Munazza Asad, Unab I. Khan, Anum Arshad
doaj   +1 more source