Results 71 to 80 of about 4,028,565 (349)

Emergency medicine and general practice [PDF]

, 2005
Emergency Medicine and Immediate Medical Care are relatively new specialties. In Malta, there is quite a considerable area of overlap between these specialties and general practice.
Abela, Gunther
core  

Next steps for the East, Central and Southern Africa College of Family Physicians (ECSA-CFP)

African Journal of Primary Health Care & Family Medicine
No abstract available.
Innocent K. Besigye, Mpundu Makasa, Martha Makwero, Jacob S. Shabani, Sunanda Ray   +4 more
doaj   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Mice lacking sialyltransferase ST3Gal-II develop late-onset obesity and insulin resistance [PDF]

, 2016
Sialyltransferases are a family of 20 gene products in mice and humans that transfer sialic acid from its activated precursor, CMP-sialic acid, to the terminus of glycoprotein and glycolipid acceptors.
Aja, Susan, Aoki, Kazuhiro, Lei, Xia, Lopez, Pablo, Ronnett, Gabriele V, Schnaar, Ronald L., Seldin, Marcus M., Wong, G. William   +7 more
core   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

A Patient Centered Intervention to Promote Primary Care Based Screening for Diabetic Retinopathy [PDF]

, 2018
Diabetic Retinopathy is the leading cause of blindness in patient\u27s age 25-74 in the world. Onset of disease is insidious and early intervention is the only way to reduce morbidity.
Earle, William B
core   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Teaching evidence based medicine in family medicine

Acta Medica Academica, 2012
The concept of evidence based medicine (EBM) as the integrationof clinical expertise, patient values and the best evidence was introduced by David Sackett in the 1980’s.
Davorka Vrdoljak
doaj  

EFFECT OF FAMILY MEDICINE TRAINING PROGRAM ON HOUSE OFFICER'S PERCEPTION OF FAMILY MEDICINE SPECIALTY IN EGYPT [PDF]

Euromediterranean Biomedical Journal
The Egypt's commitment to universal health coverage has emphasized the growing need for well-trained family physicians. Nonetheless, Family Medicine remains underrated as a career choice for medical students.
Asmaa Ahmed Sayed
doaj   +1 more source

Family medicine in Japan [PDF]

British Journal of General Practice, 2009
If you are passionate about primary care then it is always uplifting to meet people who feel the same. The argument for a structured primary care system in Japan has been ongoing for some time but it is only in the last few years that it is gathering momentum. Indeed, from a distance one might wonder why on earth Japan needs to change anything?
openaire   +3 more sources