This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Levantamento da flora apícola em municípios da microrregião de Catolé do Rocha-PB
Objetivou-se com este estudo realizar um levantamento sobre a flora apícola em municípios da microrregião de Catolé do Rocha-PB. O levantamento dos dados foi realizado através da aplicação de 55 questionários, onde foram levantados dados sobre os ...
Carlos Alberto de Lima e Silva +4 more
doaj
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Indonesian archipelago has a high necessity of sea transportation to support the trade activities and mobility between one island and another. The harbor security is an important factor to ensure the safety of the ships which are being leant there ...
Lailatul Qhomariyah
doaj
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Proposal of <i>Allobrachymonas</i> gen. nov. and three new combinations as replacement names for the illegitimate prokaryotic genus name <i>Brachymonas</i>, proposal of <i>Allobosea</i> gen. nov. and 12 new combinations as replacement names for the illegitimate prokaryotic genus name <i>Bosea</i> and proposal of <i>Alloboseaceae</i> fam. nov. as a replacement name for the illegitimate family name <i>Boseaceae</i>. [PDF]
Deshmukh UB, Oren A.
europepmc +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Correction: Clinicopathological profile of basal cell carcinoma: a retrospective study from Limpopo province, South Africa. [PDF]
Manenzhe R, McCusker CP, Mhlongo LN.
europepmc +1 more source

