The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
McCandless Family Papers - Accession 1715
The McCandless Family Papers consists of photographs and photo albums of the McCandless family, mostly from Chester, SC, and those related to them. Many of these photographs are tintypes, ambrotypes, and carte de visites.
Crawford Family +3 more
core
Proposal of <i>Allogeochorda</i> gen. nov., <i>Allogeochorda subterranea</i> comb. nov., <i>Allostigmatella</i> gen. nov. and four new combinations and <i>Allosphingorhabdus</i> gen. nov. and <i>Allosphingorhabdus lutea</i> comb. nov. as replacement names for the illegitimate genus names <i>Geochorda</i>, <i>Stigmatella</i> and <i>Alterisphingorhabdus</i> and their species. [PDF]
Kostovski M, Oren A.
europepmc +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Levi-Berlinger-Ellinger Family Collection 1863-1974
The collection contains genealogical information regarding the Levi, Berlinger, and Ellinger families. Included is a family tree from 1300 to the early 20th century; family history (in Hebrew) with family trees and index of names; and citizenship ...
Berlinger (Family) +2 more
core
Virus taxonomy and the ICTV - 21 FAQs for the perplexed virologist. [PDF]
Smith DB, Simmonds P, Siddell SG.
europepmc +1 more source
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Online Mapping - Atlas of Luxembourgish family names
This online atlas is intended to visualize the spatial distribution of family names in the Greater Region. The atlas offers the possibility to map ALL family names in Luxembourg, Belgium, The Netherlands, Germany and France.
GILLES, Peter
core
Correction: Forensic age estimation by MRI of the knee - comparison of two classifications for ossification stages in a German population. [PDF]
Malokaj V +4 more
europepmc +1 more source
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source

