Results 111 to 120 of about 1,712,892 (388)

Neutrino Masses from Generalized Symmetry Breaking

Physical Review X
We explore generalized global symmetries in theories of physics beyond the standard model. Theories of Z^{′} bosons generically contain “noninvertible” chiral symmetries, whose presence indicates a natural paradigm to break this symmetry by an ...
Clay Córdova, Sungwoo Hong, Seth Koren, Kantaro Ohmori   +3 more
doaj   +1 more source

The Theory of Gene Family Histories

Most genes are part of larger families of evolutionary related genes. The history of gene families typically involves duplications and losses of genes as well as horizontal transfers into other organisms. The reconstruction of detailed gene family histories, i.e., the precise dating of evolutionary events relative to phylogenetic tree of the underlying
Hellmuth, Marc, Stadler, Peter
openaire   +3 more sources

The tale of two centres

, 1996
We study motion in the field of two fixed centres described by a family of Einstein-dilaton-Maxwell theories. Transitions between regular and chaotic motion are observed as the dilaton coupling is varied.Comment: 20 pages, RevTeX, 7 figures included, TeX
Benci V, Biesiada M, Chandrasekhar S, Contopoulos G, Contopoulos G, Cornish N J, Dettmann C P, Fomenko A T, Gary W Gibbons, Gibbons G W, Hadamard J, Hartle J B, Hawking S W, Jacobi C G J, Manton N, Manton N, Neil J Cornish, Ott E, Papapetrou A, Robinson C, Rugh S, Sota Y, Sota Y, Szylowski M, Witt D   +24 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Theory of the third: A cybernetic approach to escalative conflict dynamics in business families [PDF]

, 2023
Lina Nagel, Steffen Roth, Heiko Kleve
openalex   +1 more source

Use of Theoretical Models in Family Therapy: Focus on Social Constructionism

Paidéia (Ribeirão Preto)
: In the field of family therapy (FT), theoretical and methodological perspectives coexist. This article aims to comprehend how family therapists use different theories, especially social constructionism.
Gabriela Silveira de Paula-Ravagnani, Carla Guanaes-Lorenzi, Emerson Fernando Rasera   +2 more
doaj   +1 more source

Entanglement constant for conformal families

, 2015
We show that in 1+1 dimensional conformal field theories, exciting a state with a local operator increases the Renyi entanglement entropies by a constant which is the same for every member of the conformal family. Hence, it is an intrinsic parameter that
Caputa, Pawel, Veliz-Osorio, Alvaro
core   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source