Results 91 to 100 of about 478,626 (316)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Family physicians beliefs and attitudes regarding adult pneumococcal and influenza immunization in Lebanon

, 2011
Background. Influenza and pneumococcal diseases are responsible for more deaths than all other vaccine-preventable diseases combined. Despite all efforts, the vaccination rate is below target.Objectives.
Romani M.H., Hamadeh G.N., Musharrafieh U.M., Lakkis N.A.   +3 more
core   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

The Spatial Distribution of Physicians in the United States: A Review of the Literature [PDF]

, 1977
One manifestation of a contemporary concern with equality in the provision of health care services is the growing interest that appears to be developing in the spatial location of medical manpower. There is no evidence that any country has ever achieved,
Butler, J.R.
core  

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

The Influence of Family Physicians Within the South African District Health System: A Cross-Sectional Study [PDF]

, 2018
PURPOSE : Evidence of the influence of family physicians on health care is required to assist managers and policy makers with human resource planning in Africa.
Indiran Govender, Robert J. Mash, Steinberg, Wilhelm Johannes, Esterhuizen, Tonya M., Laurel Baldwin-Ragaven, Baldwin-Ragaven, Laurel, Govender, Indiran, Klaus B. von Pressentin, Wilhelm Johannes Steinberg, Botha, R.P.G. (Roelf Petrus Gerhardus), Tonya M. Esterhuizen, Mash, Robert J., Von Pressentin, Klaus B., Roelf Petrus Gerhardus Botha   +13 more
core   +1 more source

Developing a national clinical competency committee for family medicine training, South Africa

Journal of the Colleges of Medicine of South Africa
Entrustable professional activities (EPAs) have been introduced into family medicine training programmes across South Africa (SA) as part of a competency-based medical education (CBME) framework.
Louis S. Jenkins, Mergan Naidoo, Kefilwe Hlabyago, Dirk T. Hagemeister, Neetha Erumeda, Busisiwe Cawe, Tasleem Ras, Mulimisi Ramavhuya, Owen Eales   +8 more
doaj   +1 more source

The Farm Fresh Healthcare Project: Analysis of a Hybrid Values-based Supply Chain

Journal of Agriculture, Food Systems, and Community Development, 2016
An emerging literature on values-based supply chains offers models for meeting both the scale-based requirements and values-based goals of farm-to-institution initiatives.
Kendra Klein, Ariane Michas
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source