Results 111 to 120 of about 6,019,168 (394)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Measurement and correlates of empathy among female Japanese physicians. [PDF]

, 2012
BACKGROUND: The measurement of empathy is important in the assessment of physician competence and patient outcomes. The prevailing view is that female physicians have higher empathy scores compared with male physicians.
Gonnella, Joseph S, Hojat, Mohammadreza, Kataoka, Hitomi U, Koide, Norio   +3 more
core   +2 more sources

The Rise of Electronic Health Record Adoption Among Family Physicians

Annals of Family Medicine, 2013
PURPOSE Realizing the benefits of adopting electronic health records (EHRs) in large measure depends heavily on clinicians and providers’ uptake and meaningful use of the technology.
Imam M. Xierali, Chun-Ju Hsiao, J. Puffer, L. Green, Jason C. B. Rinaldo, A. Bazemore, M. Burke, R. Phillips   +7 more
semanticscholar   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Review of the Book \u3ci\u3eThe Cost of Talent: How Executives and Professionals are Paid and How it Affects America\u3c/i\u3e [PDF]

, 1995
[Excerpt] Why should the former President of Harvard University be concerned that during the 1970s and 1980s the earnings of doctors, lawyers in private practice, and top corporate executives grew substantially relative to the earnings of professors ...
Ehrenberg, Ronald G
core   +1 more source

Canadian family physicians' and paediatricians' knowledge, attitudes and practices regarding A(H1N1) pandemic vaccine [PDF]

, 2010
Background: One of the main determinants of public immunization success is health professionals' support and recommendations. Little is known about the physicians' level of support and intentions regarding A(H1N1) pandemic influenza vaccination.
Eve Dubé, Vladimir Gilca, Chantal Sauvageau, Nicole Boulianne, François D Boucher, Julie A Bettinger, Shelly McNeil, Ian Gemmill, France Lavoie, Manale Ouakki, M Chan, MCG Nuno, V Sypsa, J Maurer, JTF Lau, H Seale, F Lagarde, NT Brewer, GD Zimet, P Ritvo, LJ Erickson, JSY Chor, V Gilca, V Gilca, RJ Oram, GL Freed, JC Raley, B Duval, B Duval, V Gilca, M Pareek   +30 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Predictors of spiritual care provision for patients with dementia at the end of life as perceived by physicians : a prospective study [PDF]

, 2014
Background: Spiritual caregiving is part of palliative care and may contribute to well being at the end of life. However, it is a neglected area in the care and treatment of patients with dementia.
Deliens, Luc, Gijsberts, Marie-Jose H, Hertogh, Cees MPM, van der Steen, Jenny T   +3 more
core   +2 more sources

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Physician Labour Supply in Canada: a Cohort Analysis [PDF]

This paper employs cohort analysis to examine the relative importance of different factors in explaining changes in the number of hours spent in direct patient care by Canadian general/ family practitioners (GP/FPs) over the period 1982 to 2002.
Thomas F. Crossley, Jeremiah Hurley, and Sung-Hee Jeon
core   +6 more sources