Results 61 to 70 of about 4,251,193 (309)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Seven tips for clinical supervision in the time of COVID 19

Canadian Medical Education Journal, 2020
Virtual care (VC) rapidly has become the preferred care model in family medicine settings during the COVID-19 pandemic.  Both residents and preceptors must rapidly adapt and develop new skills to provide and supervise virtual care.
Karen Schultz, Alexander Singer, Ivy Oadansan   +2 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Health budget cuts will be paid for by the most vulnerable

South African Family Practice
No abstract available.
Jenny Nash, Andrew J. Ross, Mergan Naidoo, Tasleem Ras, Hanneke Brits, Sheena Mathew   +5 more
doaj   +1 more source

Standards for Substantive Equivalency between Continuing Professional Development/Continuing Medical Education (CPD/CME) Accreditation Systems

Journal of European CME, 2021
The International Academy for Continuing Professional Development Accreditation (IACPDA) is dedicated to advocating for and enhancing the development, implementation and evolution of continuing medical education (CME)/continuing professional development (
Kate Regnier, Craig Campbell, Reinhard Griebenow, Michel Smith, Kate Runacres, Amy Smith, Graham McMahon, on behalf of the International Academy for CPD Accreditation   +7 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

The journal: A change at the helm

South African Family Practice, 2012
No abstract available.
Pierre J.T. de Villiers
doaj   +1 more source

Waterpipe smoking cessation: Knowledge, barriers, and practices of primary care physicians- A questionnaire-based cross-sectional study [PDF]

, 2020
Background: While cigarette smoking has been considered the most relevant tobacco product worldwide, waterpipe tobacco smoking (WTS) has increased in prevalence globally and calls for more considerable attention now.
Shalak, Manar, Antoun, Jumana M., Jawhar, Sarah, Romani, Maya H.   +3 more
core   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Sleep Duration and Obesity among Adults Under 65 Years of Age and the Elderly in Taiwan

International Journal of Gerontology, 2012
Background: This study investigated the determinants of obesity in adults younger than 65 years of age and those older than 65 years, focusing on the relationship between sleep duration and obesity after controlling other factors.
Meng-Ting Tsou
doaj   +1 more source