Results 161 to 170 of about 10,049,210 (380)

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Scope of work and the future of family practice. [PDF]

Can Fam Physician, 2022
Lemire F, Slade S.
europepmc   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Physicians' professionalism from the patients' perspective: a qualitative study at a single-family practice in Saudi Arabia. [PDF]

BMC Med Ethics, 2023
AlFaris E, Irfan F, Abouammoh N, Zakaria N, Ahmed AM, Kasule O, Aldosari DM, AlSahli NA, Alshibani MG, Ponnamperuma G.   +9 more
europepmc   +1 more source

Is the Ambulatory Care Educational Program for Trainees of Residency Program Adequate to Meet Their Post-Training Clinical Performance Needs?: Assessment in Family Practice Residency Program of Tertiary Hospital [PDF]

, 1970
Joon Seo Yoo, Yun Mi Song, Joo Yong Kim, Yoong Eun Kim, Ji Won Park, Hwee Su Jung   +5 more
openalex   +1 more source

Transition of patients with recently diagnosed Dementia from inpatient to outpatient setting– a scoping review

BMC Geriatrics
Introduction After being diagnosed with dementia, patients need a medical professional to empathetically address their fears and get initial questions answered.
Flora-Marie Hegerath, Chantal Giehl, Michael Pentzek, Horst Christian Vollmar, Ina Carola Otte   +4 more
doaj   +1 more source

Stress experiences of healthcare assistants in family practice at the onset of the COVID-19 pandemic: a mixed methods study. [PDF]

Front Public Health, 2023
Schrader H, Ruck J, Borgulya G, Parisi S, Ehlers-Mondorf J, Kaduszkiewicz H, Joos S, Grau A, Linde K, Gágyor I.   +9 more
europepmc   +1 more source

Traditional Attitudes, Beliefs, and Practices Relevant to Family Planning (in East Africa) [PDF]

, 1970
Luis Beltrán, Manuel De Esteve-Sabater
openalex   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source