Results 71 to 80 of about 1,570,185 (264)
Children from nuclear families with bad parental relationship could develop tic symptoms
Molecular Genetics & Genomic Medicine, 2020 Background Studies have reported the impact of chronic childhood and adolescent tic disorder (TD) on families. However, few researches focused on the relationship between family environment and diagnosis of TD.
Pengcheng Zhu +4 more
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
URDU-INCREASING TRENDS OF SUICIDE AND ITS PREVENTION IN THE LIGHT OF ISLAMIC TEACHINGS
دی اسکالرIslam believes that human life is a divine trust of Allah and it is a fundamental religious responsibility to protect it. Modern times have seen increasing suicide tendencies due to economic needs, loneliness, destruction of families, mental illnesses ...
Abdul Salam Tunio, Bashir Ahmed Rind
doaj
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Desenvolvimento em Questão, 2016 From the point of view of Urban Economics, there is clear relationship between residential location and family structure, with family with income dependent members living nearer from de location of the jobs (Central Business Districts).
Gisleia Duarte, Raul Silveira Neto
doaj
The Jar is Half-Empty and The Jar is Half-Full: Challenges and Opportunities in Graduating First-Generation African American Undergraduates [PDF]
Critical Questions in Education, 2011 A gap exists between the degree to which African Americans embrace the cultural value of higher education attainment (Butchart, 1988; Du Bois, 1935; Mickelson & Greene, 2006; Washington, 1900; Woodson, 1919) and the reality of their unsatisfactory ...
O. Gilbert Brown
doaj
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Social SciencesThis study provides a systematic examination of global research trends and developments in the field of family and marriage over a twenty-five-year period (2000–2025).
Olaniyi Joshua Olabiyi +1 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source