Results 111 to 120 of about 2,120,661 (302)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

The role of the university educational environment in forming family values: Russian students’ assessments

RUDN journal of Sociology
The article shows how Russian students assess the role of the university as a socialization institution in strengthening the value of family and in their preparing for marriage, birth and raising children.
I. E. Strelets, D. S. Mukhortov, Yu. S. Markova   +2 more
doaj   +1 more source

Forms of Social Capital in the Romanian Kinship [PDF]

Revista Română de Sociologie, 2010
This study aims at providing a theoretical and methodological preamble to the more ample issue concerning the research project entitled „Modele de interacţiune între capitalul social informal şi formal; investigarea rolului de suport şi mediator al ...
PETRU ILUŢ
doaj  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Breaking Stereotypes by Obtaining a Higher Education: Latinas\u27 Family Values and Tradition on the School Institution

, 2010
Higher education is a way to be able to reach the American Dream and help pursue a professional career. The American Dream is a common ideology in the Latino community. Low wage labor in the United States was a way to obtain that American Dream.
Gomez Cervantes, Andrea
core   +1 more source

ETHNIC FEATURES OF INFLUENCE OF FAMILY VALUES OF PARENTAL FAMILIES ON FORMATION OF STRUCTURE OF FAMILY VALUES IN YOUNG FAMILIES

Sovremennye Issledovaniâ Socialʹnyh Problem, 2013
The article deals with methodological approaches to a problem of classification of family values. Authors provide a classification of family values structure from medical and social positions: material values (money, financial position, living conditions)
Tatiana Vladimirovna Anafianova, Vladimir Fedorovich Kapitonov, Ksenia Andreyevna Bulatova   +2 more
doaj  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Institutionalizing the family business: The role of professional associations in fostering a change of values

, 2010
The authors examine the role played by a voluntary professional association as a carrier of mimetic and normative institutional pressures in the institutionalization of new governance practices among family businesses.
Gimeno, Alberto,, Maria José Parada, Alberto Gimeno, Mattias Nordqvist, Parada, Maria-José,, Nordqvist, Mattias,   +5 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Psychological readiness for marriage of boys and girls during their student years

Russian Journal of Education and Psychology
Background. Modern society is undergoing a transformation of marital and family values, which is manifested in an increasing number of divorces, postponement of marriage to a later age and the spread of alternative forms of relationships (cohabitation ...
Elena A. Mannanova, Alexandra A. Nikitinа   +1 more
doaj   +1 more source