Results 81 to 90 of about 9,981,389 (290)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
TRADATIONAL FAMILY VALUES AND CONTEMPORARY CHALLENGES OF AZERBAIJANIS [PDF]
مجلة الاجتهاد للدراسات القانونية والاقتصادية, 2019 Under conditions of globalization traditional moral values in the modern Azerbaijani family are subjected to change. The characteristic of a family's activity, which is a complicated social phenomenon, is determined by a number of different conditions ...
Dr. Nuruzade sahla
doaj
Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers
FEBS Letters, EarlyView.Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui +4 more
wiley +1 more source
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Frontiers in Pharmacology, 2016 Introduction: Health-related quality of life (HRQOL) has become an important measure to identify and shape effective and patient-relevant healthcare interventions innovations through outcomes.
Tanja Kastien-Hilka +9 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Do family values and reproductive health knowledge influence reproductive health-promoting behaviors in married women? A cross-sectional survey. [PDF]
Korean J Women Health Nurs, 2022 Yun SJ, Kim HY.
europepmc +1 more source
Exploring Community Based Responses and the Natural History of a Drug Market
Social Work and Society, 2015 Previous studies portray open drug market neighborhoods as uniformly poor, urban, socially disorganized, with weak informal social control. Further, open drug market neighborhoods appear sui genesis.
Wes Abercrombie, Mitchell Mackinem
doaj
Family leisure facilities as a driver of city development
Urbis et Orbis: Mikroistoriâ i Semiotika GorodaThe study examines the issue of developing family leisure facilities within the context of urban space management. The relevance of this problem lies in research indicating that families engaged in family leisure activities tend to be stronger ...
Oksana Gomazova +2 more
doaj +1 more source