Results 131 to 140 of about 2,120,661 (302)
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Work Values and Family Business Choices
, 2007 Family businesses are very dependent on decision-making by the owner-manager. The personal beliefs and values system of the decision-maker (owner) create a framework that guides adoption and rejection of goals and consequent behavior; similarly, beliefs ...
CUBICO, Serena
core
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
, 2012 [[abstract]]This study was aimed at exploring not only the relations between work-family role values, role commitment, work hours input and work-family conflict, but also the mediating effect of work hours input during holidays between role commitment ...
Jiang, Yi-Ping
core
Strengths of Australian Aboriginal cultural practices in family life and child rearing [PDF]
, 2014 This paper explores some of the characteristics of traditional Aboriginal and Torres Strait Islander cultural practices that contribute to effective family functioning, and how these practices can have positive effects on children and communities.
Nick Butera, Shaun Lohoar, Edita Kennedy
core
The study of family upbringing traditions as a potential for preserving spiritual and moral values
Современное дошкольное образованиеBackground. The implementation of the task of introducing children to the traditional moral values of the Russian people, socio-cultural norms and cultural traditions of their families is highlighted among the priorities in the new Federal Educational ...
Irina N. Vorobyeva +2 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Global Changes of Family Unit in Modern Russia
Astra Salvensis, 2019 The current study is relevant due to the necessity to analyze transformations in modern family-marriage relations. The objective of the study is to consider inevitability of the given transformations as an integral part of natural changes in modern ...
Igor Vasilevich MALIMONOV +6 more
doaj
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source