Results 171 to 180 of about 37,579 (307)

Porcine kidney xenotransplantation: From primate models to clinical reality

open access: yesAnimal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo   +3 more
wiley   +1 more source

Stem cell–based therapies for type 1 diabetes: Progress in differentiation, clinical translation, and immune protection

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Directed differentiation of pluripotent stem cells into functional pancreatic β cells have emerged as a promising strategy for the radical treatment of type 1 diabetes, with preclinical and early clinical evidence demonstrating reversal of hyperglycemia and insulin independence.
Zifan Li, Yu Kang, Yuyu Niu
wiley   +1 more source

Recent advances in the construction of humanized animal models and applications in translational medicine

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Substantial advances have been achieved in the development of humanized mouse models, which have proven highly valuable in evaluating cancer immunotherapies and elucidating the mechanisms of infectious diseases. There is now a growing shift in research toward larger animal models—such as pigs—that offer greater physiological similarity to humans ...
Yanan Lyu, Yong‐Guang Yang, Zheng Hu
wiley   +1 more source

Optimization of F¯ Removal From Wastewater Utilizing Alternating Current Electrocoagulation Coupled With Sonication Using a Statistical Design Approach

open access: yesAsia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT Combining electrochemical and advanced oxidation processes (AOPs) has greatly mitigated the limitations of electrocoagulation (EC) in water treatment. This study examined the effectiveness of sonolysis (US)‐assisted alternating current (AC)–EC in reducing fluoride (F¯) from landfill leachate wastewater (LLW), with measurements of electrical ...
Perumal Asaithambi   +7 more
wiley   +1 more source

Elevated risk of infectious diseases in adulthood after prenatal or early postnatal exposure to the Great Chinese Famine. [PDF]

open access: yesProc Natl Acad Sci U S A
Li Q   +11 more
europepmc   +1 more source

Unfused transverse foramen of the atlas vertebra in the Neandertal lineage fossils

open access: yesThe Anatomical Record, EarlyView.
Abstract In anatomically modern humans, the atlas can display an unfused transverse foramen (UTF) but currently the presence of UTF in the Neandertal lineage is uncertain due to a scarcity of prevalence studies and no exhaustive record of its presence throughout the entire hominin fossil record.
Asier Gómez‐Olivencia   +5 more
wiley   +1 more source

A second species of non‐crocodyliform crocodylomorph from the Late Triassic fissure deposits of southwestern UK: Implications for locomotory ecological diversity in Saltoposuchidae

open access: yesThe Anatomical Record, EarlyView.
Abstract The Late Triassic–Early Jurassic fissures of the Bristol Channel area (southwest England and south Wales) are renowned for their diverse vertebrate faunas. These assemblages have yielded an array of predominantly small‐bodied forms that are crucial to our understanding of the early evolution of several major tetrapod clades.
Ewan H. Bodenham   +4 more
wiley   +1 more source

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