Results 91 to 100 of about 66,919 (281)

Development‐based In Vivo Bioreactor Strategy for Challenging Senescent Bone Reconstruction

Advanced Science, EarlyView.
We present a development‐based in vivo bioreactor strategy to generate rejuvenated bone grafts (vBR‐Bone) within aged hosts. By enclosing vBR‐Bone fragments within an asymmetric biomimetic periosteum, segmental femoral defects in aged mice were successfully repaired within 6 weeks. Mechanistically, the multifactors of vBR‐Bone reconstitute a remodeling
Wenchao Zhang, Kai Dai, Tong Shen, Zehua Gao, Fengying Yan, Yuke Feng, Xuanlin Wang, Shaozhen Zhang, Jing Wang, Changsheng Liu   +9 more
wiley   +1 more source

Long-term Effects of Famine on Life Expectancy: A Re-analysis of the Great Finnish Famine of 1866-1868 [PDF]

Famines are extreme cases of environmental stress, and have been used by a series of studies to explore the long-term consequences of the fetal or childhood environment. Results are inconsistent and do not support negative long-term effects on mortality.
Doblhammer, Gabriele, Lumey, Lambert H., van den Berg, Gerard J.   +2 more
core  

Systematic Engineering of Proteases in Saccharopolyspora Spinosa Reveals Synergistic Enhancement of Spinosad Biosynthesis via Substrate Flux Optimization

Advanced Science, EarlyView.
ARTP mutagenesis yielded Saccharopolyspora spinosa mutant D184 with improved extracellular nitrogen utilization. An integrated workflow of protease genetic manipulation, multi‐omics, and rational synergy design pinpointed a pepP‐clpP‐htpX synergistic triangular combination.
Duo Jin, Wangqiong Chen, Danlu Yang, Qing Liu, Baolong Bai, Zirui Dai, Xirong Liu, Zirong Zhu, Jie Rang, Liqiu Xia   +9 more
wiley   +1 more source

Exposure to Chinese famine in early life and the risk of multimorbidity in adulthood

BMC Public Health
Objectives Previous studies had reported the association between famine exposure in early life and subsequent non-communicable diseases risk. In current study, we aimed to evaluate the associations between famine exposure on multimorbidity prevalence and
Jiahui Zhang, Le Zhang, Wenyan Wu, Xiaowei Zheng   +3 more
doaj   +1 more source

Fetal and infant exposure to severe Chinese famine increases the risk of adult dyslipidemia: Results from the China health and retirement longitudinal study

BMC Public Health, 2017
Background To explore the associations between the Chinese famine exposure in early life and the dyslipidemia in adulthood. Methods We selected 2752 participants from the baseline survey of China Health and Retirement Longitudinal Study (CHARLS) 2011 ...
Zhenghe Wang, Changwei Li, Zhongping Yang, Jun Ma, Zhiyong Zou   +4 more
doaj   +1 more source

Effects of Prenatal and Early Life Malnutrition: Evidence from the Greek Famine [PDF]

This paper examines the long run education and labor market effects from early-life exposure to the Greek 1941-42 famine. Given the short duration of the famine, we can separately identify the famine effects for cohorts exposed in utero, during infancy ...
Sven Neelsen, Thomas Stratmann
core  

Polyelectrolyte Design Principles for Electrophoretic Drug Delivery

Advanced Science, EarlyView.
Structure–property–function mapping of polyelectrolytes reveals how composition and nanoscale order control on‐demand electrophoretic drug transport. Charge density quantified under implant‐relevant conditions shows that encapsulation limits swelling, enabling high effective charge density.
Helena Saarela Unemo, Iwona Bernacka‐Wojcik, Lingkai Zhu, Marle E. J. Vleugels, Moa E. Hörberg, Caroline Lindholm, Magnus Berggren, Daniel T. Simon, Theresia Arbring Sjöström   +8 more
wiley   +1 more source

The Lasting Damage to Mortality of Early-Life Adversity: Evidence from the English Famine of the late 1720s [PDF]

This paper explores the long-term impact on mortality of exposure to early-life hardship. Using survival analysis, we document that birth during the great English famine of the late 1720s manifest itself in an increased death risk throughout life among ...
Jacob Weisdorf, Marc Klemp
core  

Reporting the Irish Famine in America: Images of Suffering Ireland in the American Press, 1845-1848 [PDF]

, 2014
This chapter is a study of American newspaper reporting on the Great Irish Famine. The study examines six master narratives that constrained the image of Ireland and the Irish people presented to American readers.
Farrell, James M.
core   +1 more source

Maternal nutritional status, C1 metabolism and offspring DNA methylation: a review of current evidence in human subjects. [PDF]

, 2011
: Evidence is growing for the long-term effects of environmental factors during early-life on later disease susceptibility. It is believed that epigenetic mechanisms (changes in gene function not mediated by DNA sequence alteration), particularly DNA ...
Cox, SE, Dominguez-Salas, P, Hennig, BJ, Moore, SE, Prentice, AM   +4 more
core   +4 more sources