Results 121 to 130 of about 19,342 (292)
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
, 2008 Edwards v. Attorney General of Canada ( the Persons case ) is a landmark Canadian legal decision. By petition of the Famous Five, this case determined in 1929 that women were persons qualified to be appointed to the Senate, and it coined the living ...
Koshan, Jennifer
core
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
TOPOGRAPHIC HAZARD VIEWED ON AERIAL PHOTOGRAPHS-HISTORICALLY FAMOUS DISASTERS (Part I)-
, 1981 Mass movement or landslide often brings serious hazards, to say the 'topographic hazards', that kill a number of persons in Japan, if the movement is sudden and rapid, and if the amount ofmoving material is large. A number of examples of such disasterous
平野, 昌繁
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
U današnjem svijetu, gdje se marketing neprestano razvija i oblikuje, uloga poznatih osoba kao ambasadora luksuznih modnih marki postaje sve značajnija.
Mrvoš, Anamaria
core +2 more sources
Otorhinolaryngeal diseases in old age and in famous persons.
Acta medica (Hradec Kralove), 1997 Diseases of the ear, nose and throat influenced or played an important role in the lives of painters (D. Ghirlandaio, L. da Vinci, L. van Leyden, J. Reynolds, F. Goya, V. van Gogh), composers (L. van Beethoven, B. Smetana, G. Puccini, M. Ravel, J. Jezek), writers or poets (W. Shakespeare, O. Wilde), statesmen (Francis II, John VI., G.
openaire +1 more source