Results 141 to 150 of about 560,227 (291)
Congress and Literacy Tests: A Comment on Constitutional Power and Legislative Abnegation [PDF]
, 1962 Maggs, Douglas B., Wallace, Lawrence G.
core +2 more sources
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Some Cultural Aspects of Immigration: Its Impact, Especially on Our Arts and Sciences [PDF]
, 1956 Burma, John Harmon
core +2 more sources
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Modality-Specific and Multimodal 'Associative' Forms of Face and Voice Recognition Disorders in Patients with Right Anterior Temporal Lesions: A Review of Single-Case Studies. [PDF]
Brain SciGainotti G.
europepmc +1 more source
Otorhinolaryngeal diseases in old age and in famous persons.
Acta medica (Hradec Kralove), 1997 Diseases of the ear, nose and throat influenced or played an important role in the lives of painters (D. Ghirlandaio, L. da Vinci, L. van Leyden, J. Reynolds, F. Goya, V. van Gogh), composers (L. van Beethoven, B. Smetana, G. Puccini, M. Ravel, J. Jezek), writers or poets (W. Shakespeare, O. Wilde), statesmen (Francis II, John VI., G.
openaire +1 more source
Rising Stars, Superstars and Dying Stars: Hedonic Explorations of Autograph Prices [PDF]
Key studies have explored the economics of rising stars, superstars and ‘has beens’, but relatively little economic literature exists on the associated parallel memorabilia markets.
Alan Collins +2 more
core
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source