Targeting the LINC01140/miR‐942‐5p/NRXN1 axis may be able to inhibit CRC progression by simultaneously regulating the functions of tumor cells and CAFs, which might significantly enhance the clinical efficacy of targeted therapy. ABSTRACT Long non‐coding RNAs play a wide role in colorectal cancer (CRC).
Jian Zhao, Songjie Liu, Bing Xu
wiley +1 more source
Translational Theranostics in Glioblastoma: FAPI-46 as a Precision Medicine Tool. [PDF]
Jeanjean P +14 more
europepmc +1 more source
Senescent Mesenchymal Stromal Cells Drive Stem Cell Aging Through Dysregulated Chemokine Synthesis
Senescent MSCs do more than fuel inflammaging: they disrupt the chemokine signals that maintain stem cell function. We propose that restoring this signaling balance through senolytics, senomorphics, or MSC rejuvenation may preserve regenerative capacity during aging. ABSTRACT Aging is accompanied by a progressive decline in tissue regenerative capacity,
Shaianne N. Stein, Lorena R. Braid
wiley +1 more source
FAP as a Clinical Biomarker: FAP+ CAFs Orchestrate an Immunosuppressive Stem Cell Niche via the COL1A1/2-CD44 Axis in Colon Cancer. [PDF]
Ding Q, Lu Q.
europepmc +1 more source
Abstract Aims To investigate the barriers and facilitators to adopting healthy lifestyle habits among patients with type 2 diabetes mellitus (T2DM) in the Brazilian Amazon, using the Environmental Factors domain of the International Classification of Functioning, Disability and Health (ICF) as a conceptual framework.
Thalyta Mariany Rêgo Lopes Ueno +5 more
wiley +1 more source
Preclinical evaluation of homodimeric FAPI target modules for UniCAR-mediated targeting of FAP-expressing tumor and stromal cells. [PDF]
Boutier H +15 more
europepmc +1 more source
Erosion Potential of Commercial Fluoride‐Free Mouthwashes on Dental Hard Tissues
ABSTRACT Purpose Mouthwashes often present acidic pH, which raises concerns about their potential contribution to erosive tooth wear. This study evaluated the erosive potential of commercial fluoride‐free mouthwashes using a screening method.
Astrid C. Valdivia‐Tapia +5 more
wiley +1 more source
Targeting cancer-associated fibroblasts: therapeutic strategies, translational challenges, and future perspectives. [PDF]
Jiang Y +8 more
europepmc +1 more source
Ocular Manifestations of Infectious Salmon Anaemia Virus Infection in Atlantic Salmon (Salmo salar)
ABSTRACT Eyes are essential sensory organs needed by teleost Atlantic salmon for high visual acuity and survival in both the wild and in aquaculture settings. In this work, we assessed the ocular manifestations of Infectious Salmon Anaemia Virus (ISAV) infection in Atlantic salmon by a cohabitation‐mediated infection assay and histological and ...
Emily Mahon +12 more
wiley +1 more source

