Results 1 to 10 of about 4,179 (208)

Subclass Analysis of Malignant, Inflammatory and Degenerative Pathologies Based on Multiple Timepoint FAPI-PET Acquisitions Using FAPI-02, FAPI-46 and FAPI-74

Cancers, 2022
Purpose: FAPI-PET is a promising imaging technique for various malignant as well as non-malignant pathologies. In a recent retrospective analysis, we evaluated the diagnostic value of repetitive early FAPI-PET-imaging with FAPI-02, FAPI-46 and FAPI-74 for malignant, inflammatory/reactive and degenerative pathologies.
Manuel Röhrich, Peter E Huber, Hans-Ulrich Kauczor   +2 more
exaly   +4 more sources

Optimizing FAPI homodimers for theranostic applications: The impact of the linker design in DOTAGA.Glu₂.(FAPI)₂ and DOTAGA.PEG₂.Glu.(FAPI)₂. [PDF]

Eur J Nucl Med Mol Imaging
Abstract Purpose This study evaluated the imaging performance, tumor retention, and therapeutic potential of two new FAPI homodimers, DOTAGA.Glu 2 .(FAPI) 2 and DOTAGA.PEG
Kumar N, Bilinska A, Menéndez E, Stephan S, Rösch F, Rominger A, Gourni E.   +6 more
europepmc   +3 more sources

99mTc-FAPI-YQ3 SPECT/CT for characterizing FAPI uptake phenotypes and metabolic-stromal heterogeneity in advanced differentiated thyroid carcinoma: a prospective single-center imaging-radiomics study [PDF]

Frontiers in Immunology
ObjectiveAdvanced and metastatic differentiated thyroid carcinoma (DTC), particularly radioactive iodine (RAI)-refractory disease, is characterized by spatially heterogeneous tumor biology and limited therapeutic options.
Peng Zhou, Pengjun Zhang, Pengjun Zhang, Yang Luo, Liang Shi, Jun Wang, Xiaochen Yao, Tao Qian, Jianhua Wang, Yueqing Gu, Feng Wang   +10 more
doaj   +3 more sources

FAPI-04 PET/CT Using [18F]AlF Labeling Strategy: Automatic Synthesis, Quality Control, and In Vivo Assessment in Patient

Frontiers in Oncology, 2021
68Ga labeled FAPI is the current standard for FAPI-PET, but its batch activity is limited. [18F]AlF-NOTA-FAPI-04 is a promising alternative combining the advantages of a chelator-based radiolabeling method with the unique properties of fluorine-18.
Xiao Jiang, Shirong Chen, Yutang Yao
exaly   +3 more sources

Integrated Multi‐Time‐Point 18F‐FAPI PET/CT and Immune Histopathology for Predicting Pathological Complete Response in Microsatellite‐Stable Locally Advanced Rectal Cancer Treated With Neoadjuvant Radiotherapy, Chemotherapy, and Immunotherapy [PDF]

MedComm (2020)
Serial multi‐time‐point 18F‐FAPI PET/CT‐derived stromal kinetics and baseline immune‐histopathological features, including iTLS count and B‐cell density, jointly predicted pCR in MSS locally advanced rectal cancer. The resulting four‐variable model achieved a mean nested cross‐validated AUC of 0.874.
He M, Yang H, Shi Y, Zhang R, Wan T, Pang X, Zhang Z, Huang L.   +7 more
europepmc   +2 more sources

¹⁸F‑FAPI‑04 PET/CT imaging of fibroblast activating protein reveals myocardial injury beyond cancer staging. [PDF]

Precis Radiat Oncol
Early detection of myocardial injury in cancer patients remains challenging with conventional diagnostic tools. 18F‐FAPI‐04 PET/CT revealed abnormal myocardial uptake associated with cardiovascular risk factors and biomarkers. 18F‐FAPI‐04 PET/CT enables early, noninvasive detection of myocardial injury, providing additional clinical value beyond cancer
Jia J, Zhou C, Yi S, Zheng J, Li C, Qin J, Wei Y.   +6 more
europepmc   +2 more sources

Comparison of [68Ga]-FAPI PET/CT and [18F]-FDG PET/CT in Multiple Myeloma: Clinical Experience

Tomography, 2022
Objective: In this study, we aimed to compare [68Ga]FAPI PET/CT and [18F]FDG PET/CT imaging to detect lesions in multiple myeloma. Methods: A total of 14 patients with multiple myeloma who underwent [68Ga]FAPI PET/CT and [18F]FDG PET/CT imaging were ...
Tülay Kuş, İlkay Doğan, Yusuf Burak ÇAYIRLI   +2 more
exaly   +3 more sources

Development of FAPI Tetramers to Improve Tumor Uptake and Efficacy of FAPI Radioligand Therapy

Journal of Nuclear Medicine, 2023
Radiolabeled fibroblast activation protein (FAP) inhibitors (FAPIs) have shown promise as cancer diagnostic agents; however, the relatively short tumor retention of FAPIs may limit their application in radioligand therapy. In this paper, we report the design, synthesis, and evaluation of a FAPI tetramer.
Pang, Yizhen, Zhao, Liang, Fang, Jianyang, Chen, Jianhao, Meng, Lingxin, Sun, Long, Wu, Hua, Guo, Zhide, Lin, Qin, Chen, Haojun   +9 more
openaire   +2 more sources

Preclinical evaluation and pilot clinical study of [18F]AlF-labeled FAPI-tracer for PET imaging of cancer associated fibroblasts

Acta Pharmaceutica Sinica B, 2022
In recent years, fibroblast activation protein (FAP) has emerged as an attractive target for the diagnosis and radiotherapy of cancers using FAP-specific radioligands.
Kongzhen Hu, Junqi Li, Lijuan Wang, Yong Huang, Li Li, Shimin Ye, Yanjiang Han, Shun Huang, Hubing Wu, Jin Su, Ganghua Tang   +10 more
doaj   +1 more source

[68Ga]FAPI-PET/CT for radiation therapy planning in biliary tract, pancreatic ductal adeno-, and adenoidcystic carcinomas

Scientific Reports, 2022
Biliary-tract-carcinomas (BTC), pancreatic-ductal-adenocarcinomas (PDAC) and adenoidcystic-carcinomas (AC) have in common that they are traditionally treated with large clinical-target-volumes (CTV).
Nika Guberina, Lukas Kessler, Christoph Pöttgen, Maja Guberina, Martin Metzenmacher, Ken Herrmann, Maja Mucha, Christoph Rischpler, Frank Indenkämpen, Jens T. Siveke, Jürgen Treckmann, Lale Umutlu, Stefan Kasper, Wolfgang P. Fendler, Martin Stuschke   +14 more
doaj   +1 more source