Results 61 to 70 of about 1,053,086 (266)

Closed-Form Expressions for LoS User Localization at an Uniform Linear Array Applicable to Both Near-Field and Far-Field

IEEE Access
We present a scheme for line-of-sight user localization at a uniform linear array (ULA) applicable to both near-field and far-field. The proposed scheme leads to closed-form expressions for the estimates of the user location, distance and angle.
Nikola Zlatanov, Manjesh Kumar Hanawal, Alexey Frolov, Kirill Andreev   +3 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Identification of Near-Field and Far-Field Using Confocal Microscopy Setup for Optical Sensing Applications

ASM Science Journal, 2019
The presence of near-field indicates the existence of evanescent waves, which is one of the important requirements for the development of an optical sensor.
Wan Maisarah Mukhtar, Nor Zahirah Mohd Zulkifli, Razman Mohd Halim   +2 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Quantifying the local density of optical states of nanorods by fluorescence lifetime imaging

New Journal of Physics, 2014
In this paper, we demonstrate a facile far-field approach to quantify the near-field local density of optical states (LDOS) of a nanorod using CdTe quantum dot (QD) emitters tethered to the surface of the nanorods as beacons for optical read-outs.
Jing Liu, Xunpeng Jiang, Satoshi Ishii, Vladimir Shalaev, Joseph Irudayaraj   +4 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Cylindrical microlasers: emission research and machine learning-assisted analysis between ASE and lasing phenomena

JPhys Photonics
Miniature polymeric cylindrical lasers, fabricated using SU-8 photoresist doped with rhodamine B at a fixed concentration of 0.5%wt, can generate amplified spontaneous emission, optical lasing, and random lasing (RL).
U A Barajas-Sánchez, E Ortiz-Ricardo, L C Padierna, H M Reynoso-de la Cruz, A González-Vega, I Rosas-Román, G Ramos-Ortiz, G Gutiérrez-Juárez, G V Vázquez, R Castro-Beltrán   +9 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source