Results 71 to 80 of about 13,209,149 (311)

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Hybrid multilevel plane wave based near-field far-field transformation utilising combined near- and far-field translations [PDF]

Advances in Radio Science, 2009
The radiation of large antennas and those operating at low frequencies can be determined efficiently by near-field measurement techniques and a subsequent near-field far-field transformation. Various approaches and algorithms have been researched but for
C. H. Schmidt, T. F. Eibert
doaj  

OTA testing of near‐field and far‐field communication links

Electronics Letters, 2023
In this work, near‐field and far‐field link measurement in metal enclosure environment is performed. The performance of near‐field and far‐field links are assessed using key performance indicators such as error vector magnitude, bit error rate, and ...
B. Korunur Engiz, M. Lodro, S. Greedy, D.W.P. Thomas   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Helicity-delinked manipulations on surface waves and propagating waves by metasurfaces

Nanophotonics, 2020
Although many approaches have been proposed to manipulate propagating waves (PWs) and surface waves (SWs), usually each operation needs a separate meta-device, being unfavorable for optical integrations.
Li Shiqing, Wang Zhuo, Dong Shaohua, Yi Sixiong, Guan Fuxin, Chen Yizhen, Guo Huijie, He Qiong, Zhou Lei, Sun Shulin   +9 more
doaj   +1 more source

Plasmonic Nanocavity Modes: From Near-Field to Far-Field Radiation [PDF]

ACS Photonics, 2019
In the past decade, advances in nanotechnology have led to the development of plasmonic nanocavities which facilitate light-matter strong coupling in ambient conditions.
N. Kongsuwan, A. Demetriadou, Matthew J. Horton, R. Chikkaraddy, J. Baumberg, O. Hess   +5 more
semanticscholar   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Experimental Study of PWM-Controlled Emission From a Large-Aperture VCSEL

IEEE Photonics Journal
This study demonstrates the use of pulse-width modulation (PWM) for mode selection in a large-aperture vertical-cavity surface-emitting laser (VCSEL). Experimental results reveal that driving the device with 1 kHz PWM pulses maintains a stable far-field ...
Miroslav Slouka, Dalibor Javurek, Erik Hendrych, Marcel Stofik, Martin Kutac, Jan Latal   +5 more
doaj   +1 more source