Results 71 to 80 of about 10,332,111 (245)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Contrasting interactions between photon spectra and temperature in cold-sensitive basil and cold-tolerant lettuce

Frontiers in Plant Science
Blue (B; 400–499 nm) light, far-red (FR; 700–750 nm) light, and temperature are key regulators of plant growth and development, with responses varying by species.
Jiyong Shin, Bruce Bugbee, Erik S. Runkle   +2 more
doaj   +1 more source

Evaluating the Effectiveness of Red Light Running Camera Enforcement in Cedar Rapids and Developing Guidelines for Selection and Use of Red Light Running Countermeasures Final Report, November 2011 [PDF]

, 2012
Red light running (RLR) is a problem in the US that has resulted in 165,000 injuries and 907 fatalities annually. In Iowa, RLR-related crashes make up 24.5 percent of all crashes and account for 31.7 percent of fatal and major injury crashes at ...

core  

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Effect of far-red light on red light-induced resistance of broad bean infected by Alfernaria tenuissima

, 2005
Effect of far-red light on lesion development in broad bean leaflets inoculated with Alternaria tenuissima was investigated. Lesion development by A. tenuissima was significantly inhibited under red light.
Honda, Yuichi, Ueno, Makoto, Kihara, Junichi, Arase, Sakae, Md. Zahidur Rahman   +4 more
core   +1 more source

Mustard ‘Amara’ Benefits from Superelevated CO2 While Adapting to Far-red Light Over Time

HortScience
Compared with the ambient Earth carbon dioxide concentration (≈415 μmol⋅mol–1), the International Space Station has superelevated carbon dioxide (≈2800 μmol⋅mol–1), which can be a stressor to certain crops.
Emily J. Kennebeck, Qingwu Meng
doaj   +1 more source

Red/Far-Red Light Switchable Cargo Attachment and Release in Bacteria-Driven Microswimmers

, 2019
In bacteria-driven microswimmers, i.e., bacteriabots, artificial cargos are attached to flagellated chemotactic bacteria for active delivery with potential applications in biomedical technology.
Wegner, S., Sentürk, O., Schauer, O., Chen, F., Sourjik, V.   +4 more
core   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Interactions between Blue Light and Far-Red Radiation on Growth of Culinary Herb Seedlings

HortScience
The photon spectrum (light quality) can regulate growth and quality characteristics of young plants, but responses of culinary herb transplants are not well described. Blue light (400 to 499 nm) generally inhibits extension growth while far-red radiation
Bridget M. Knight, Erik S. Runkle
doaj   +1 more source